Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLITRK4 | ENSG00000179542 | 1.11 | 1.27 | 0.83 | 1.09 | 0.00 | 1.61 | 0.00 | 2.76 | 1.29 | 2.99 | 0.00 | 0.81 | 0.36 | 0.00 | 0.59 | 1.94 | 6.03 | 3.86 | 0.00 | 1.23 | 0.00 | 0.56 | 0.41 | 3.13 | 0.00 | 5.45 | 2.17 | 0.00 | 0.20 | 0.83 | 4.21 | 0.00 | 0.00 |
| NPR1 | ENSG00000169418 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 1.61 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.54 | 0.36 | 0.74 | 0.20 | 0.28 | 1.69 | 1.29 | 1.23 | 1.23 | 0.00 | 0.00 | 0.00 | 3.91 | 0.00 | 2.37 | 1.63 | 0.00 | 0.41 | 0.83 | 1.11 | 1.82 | 0.00 |
| MSLN | ENSG00000102854 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.65 | 8.11 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 1.13 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.86 | 1.90 | 0.27 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| ABCC6 | ENSG00000091262 | 2.22 | 1.27 | 0.52 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 1.63 | 1.07 | 0.00 | 0.00 | 1.11 | 1.51 | 1.29 | 0.00 | 0.98 | 1.15 | 0.00 | 0.20 | 3.13 | 0.00 | 6.87 | 1.08 | 0.69 | 0.00 | 0.00 | 3.33 | 0.00 | 0.00 |
| CPD | ENSG00000108582 | 0.00 | 4.83 | 0.21 | 0.73 | 2.86 | 0.65 | 0.00 | 2.21 | 1.29 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.69 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RTN4 | ENSG00000115310 | 0.00 | 1.27 | 0.93 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.59 | 0.00 | 0.54 | 0.36 | 0.74 | 0.20 | 1.11 | 0.75 | 1.93 | 0.00 | 0.74 | 0.57 | 0.56 | 0.00 | 0.00 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC1A4 | ENSG00000115902 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC9A4 | ENSG00000180251 | 0.00 | 3.31 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 2.32 | 0.80 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 1.39 | 4.14 | 2.58 | 1.23 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.43 | 8.77 | 1.63 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC5A1 | ENSG00000100170 | 0.00 | 1.02 | 0.00 | 0.73 | 2.86 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.39 | 2.26 | 2.15 | 0.00 | 0.74 | 0.00 | 0.56 | 0.00 | 0.00 | 0.86 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| ENPP3 | ENSG00000154269 | 0.00 | 1.02 | 0.31 | 1.82 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.56 | 2.26 | 4.08 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.84 | 0.54 | 0.69 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| LY6K | ENSG00000160886 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PLAUR | ENSG00000011422 | 0.00 | 1.53 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD14 | ENSG00000170458 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| THBS1 | ENSG00000137801 | 0.00 | 2.04 | 0.83 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 2.06 | 1.39 | 0.00 | 1.90 | 1.78 | 0.00 | 0.39 | 1.11 | 0.56 | 0.64 | 0.00 | 1.23 | 0.57 | 0.00 | 0.41 | 0.78 | 1.29 | 4.98 | 1.36 | 0.00 | 0.20 | 0.00 | 2.22 | 0.00 | 1.25 |
| CXCR4 | ENSG00000121966 | 0.00 | 0.76 | 0.00 | 1.46 | 0.00 | 0.65 | 5.41 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.28 | 0.56 | 1.50 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CCR5 | ENSG00000160791 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GLP1R | ENSG00000112164 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.00 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| LPAR1 | ENSG00000198121 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 1.03 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 3.32 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| PTGER3 | ENSG00000050628 | 0.00 | 0.76 | 0.31 | 1.09 | 0.00 | 0.97 | 2.70 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.71 | 1.47 | 0.00 | 1.67 | 1.88 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 3.32 | 0.54 | 0.69 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| GRM1 | ENSG00000152822 | 2.22 | 4.33 | 0.72 | 1.09 | 0.00 | 3.55 | 2.70 | 3.31 | 1.29 | 4.78 | 0.00 | 0.81 | 0.36 | 0.74 | 0.00 | 1.67 | 6.03 | 7.73 | 1.23 | 0.98 | 1.72 | 0.00 | 1.63 | 2.34 | 0.86 | 2.61 | 5.42 | 0.69 | 0.00 | 0.00 | 3.55 | 0.00 | 0.00 |
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