Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CHRNA3 | ENSG00000080644 | 1.11 | 0.51 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 0.86 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 3.08 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ADCY9 | ENSG00000162104 | 0.00 | 1.78 | 1.03 | 2.19 | 0.00 | 2.26 | 0.00 | 1.66 | 1.80 | 1.39 | 0.00 | 1.08 | 1.07 | 0.00 | 0.59 | 1.11 | 1.69 | 1.29 | 0.00 | 1.23 | 0.57 | 0.00 | 0.41 | 0.78 | 0.43 | 1.66 | 0.81 | 0.00 | 0.41 | 0.00 | 2.00 | 1.82 | 0.00 |
| ICAM2 | ENSG00000108622 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD7 | ENSG00000173762 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CD70 | ENSG00000125726 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 10.81 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| FCER2 | ENSG00000104921 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 0.95 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| MUC16 | ENSG00000181143 | 13.33 | 25.70 | 9.81 | 15.69 | 8.57 | 19.03 | 16.22 | 22.10 | 13.66 | 18.33 | 4.62 | 8.13 | 9.25 | 2.94 | 6.86 | 16.39 | 38.61 | 37.12 | 1.23 | 9.07 | 6.90 | 3.37 | 6.11 | 18.75 | 10.78 | 64.93 | 25.47 | 1.39 | 2.04 | 4.96 | 16.63 | 7.27 | 5.00 |
| ICAM3 | ENSG00000076662 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| BCAM | ENSG00000187244 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.77 | 0.20 | 0.00 | 0.27 | 1.07 | 0.74 | 0.20 | 0.28 | 0.94 | 0.86 | 0.00 | 0.74 | 1.15 | 0.00 | 0.41 | 0.78 | 0.43 | 3.55 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SIGLEC7 | ENSG00000168995 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 1.72 | 5.69 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC8A1 | ENSG00000183023 | 1.11 | 2.04 | 0.93 | 1.09 | 0.00 | 1.61 | 0.00 | 2.76 | 0.26 | 2.39 | 0.00 | 0.27 | 1.07 | 0.00 | 0.20 | 2.22 | 7.72 | 7.08 | 0.00 | 1.23 | 0.00 | 0.00 | 0.81 | 0.78 | 0.00 | 6.87 | 2.17 | 0.69 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| SIRPA | ENSG00000198053 | 0.00 | 0.76 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.00 | 1.88 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| THBD | ENSG00000178726 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 1.11 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD96 | ENSG00000153283 | 0.00 | 1.27 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 1.13 | 2.36 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 4.50 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CD80 | ENSG00000121594 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 1.11 | 0.00 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| GP5 | ENSG00000178732 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| PROM1 | ENSG00000007062 | 1.11 | 1.27 | 0.52 | 1.09 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.83 | 1.13 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 2.34 | 0.86 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| NPR3 | ENSG00000113389 | 1.11 | 1.53 | 0.52 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.79 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.83 | 3.20 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| RECK | ENSG00000122707 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 1.59 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.00 | 0.56 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 0.81 | 0.69 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| IL13RA2 | ENSG00000123496 | 0.00 | 0.00 | 0.52 | 1.09 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.88 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.18 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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