Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KIR2DL3 | ENSG00000243772 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.11 | 1.13 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PLA2R1 | ENSG00000153246 | 0.00 | 3.05 | 0.62 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 2.22 | 2.26 | 1.07 | 1.23 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 6.16 | 1.63 | 0.00 | 0.41 | 0.00 | 2.88 | 1.82 | 0.00 |
| SIGLEC1 | ENSG00000088827 | 0.00 | 2.29 | 0.52 | 1.82 | 0.00 | 1.61 | 0.00 | 3.87 | 0.77 | 1.79 | 0.00 | 0.54 | 0.00 | 1.47 | 0.39 | 1.39 | 2.64 | 5.58 | 0.00 | 1.47 | 1.72 | 0.00 | 0.81 | 3.13 | 0.86 | 4.98 | 2.71 | 0.69 | 0.00 | 0.00 | 4.21 | 0.00 | 1.25 |
| PRNP | ENSG00000171867 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PROCR | ENSG00000101000 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| CD40 | ENSG00000101017 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GGT1 | ENSG00000100031 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.20 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| EPHA3 | ENSG00000044524 | 0.00 | 4.83 | 0.62 | 2.19 | 0.00 | 2.58 | 5.41 | 2.76 | 1.29 | 2.99 | 0.00 | 0.27 | 1.07 | 0.74 | 1.18 | 2.22 | 7.16 | 7.73 | 1.23 | 1.23 | 0.00 | 0.56 | 1.02 | 0.78 | 0.86 | 6.87 | 4.88 | 0.69 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| CD200 | ENSG00000091972 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| C6orf25 | ENSG00000204420 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| RAMP3 | ENSG00000122679 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| QSOX2 | ENSG00000165661 | 0.00 | 0.51 | 0.41 | 1.09 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 1.69 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SCNN1D | ENSG00000162572 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 1.54 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| GRIK3 | ENSG00000163873 | 0.00 | 2.54 | 0.52 | 1.46 | 0.00 | 4.52 | 0.00 | 1.10 | 1.29 | 1.39 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.83 | 2.64 | 4.72 | 1.23 | 1.23 | 1.15 | 0.00 | 1.02 | 3.13 | 2.16 | 5.45 | 1.08 | 0.69 | 0.00 | 0.83 | 3.33 | 1.82 | 1.25 |
| ABCC2 | ENSG00000023839 | 1.11 | 1.53 | 0.62 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.00 | 0.00 | 0.27 | 1.42 | 0.00 | 0.00 | 1.11 | 1.13 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.13 | 2.17 | 0.00 | 0.41 | 0.83 | 2.88 | 1.82 | 0.00 |
| SLC43A1 | ENSG00000149150 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.71 | 3.68 | 0.20 | 0.83 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 1.39 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| KLRC1 | ENSG00000134545 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC11A2 | ENSG00000110911 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| ITGA5 | ENSG00000161638 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 1.94 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.71 | 0.74 | 0.20 | 0.28 | 1.69 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 4.50 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD63 | ENSG00000135404 | 1.11 | 0.76 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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