Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| VIPR1 | ENSG00000114812 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CD86 | ENSG00000114013 | 0.00 | 1.53 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.28 | 1.69 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 4.03 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| EDNRA | ENSG00000151617 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HLA-DRB1 | ENSG00000196126 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| S1PR3 | ENSG00000213694 | 0.00 | 0.00 | 0.21 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 0.64 | 1.23 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CXCR3 | ENSG00000186810 | 1.11 | 0.51 | 0.72 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.56 | 0.64 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CD2 | ENSG00000116824 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 3.79 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| FCRL6 | ENSG00000181036 | 0.00 | 1.53 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.79 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FCGR2B | ENSG00000072694 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| ITGA8 | ENSG00000077943 | 0.00 | 3.31 | 0.62 | 1.82 | 0.00 | 2.26 | 0.00 | 3.31 | 1.03 | 3.78 | 1.54 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 6.97 | 7.08 | 1.23 | 1.47 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 6.16 | 1.36 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| CD6 | ENSG00000013725 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.83 | 1.51 | 0.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CD5 | ENSG00000110448 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.94 | 0.86 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| TMPRSS5 | ENSG00000166682 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PRIMA1 | ENSG00000175785 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LINGO1 | ENSG00000169783 | 0.00 | 1.02 | 0.31 | 1.82 | 0.00 | 1.61 | 2.70 | 1.66 | 0.26 | 1.39 | 0.00 | 0.81 | 0.00 | 0.74 | 0.00 | 0.83 | 1.32 | 2.15 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.00 | 1.29 | 0.71 | 1.08 | 0.00 | 0.41 | 0.00 | 1.77 | 0.00 | 0.00 |
| TNFRSF17 | ENSG00000048462 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SEMA6B | ENSG00000167680 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 1.20 | 1.54 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 1.88 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.54 | 0.69 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD22 | ENSG00000012124 | 0.00 | 1.53 | 0.41 | 1.09 | 0.00 | 1.29 | 0.00 | 1.10 | 1.55 | 0.40 | 0.00 | 0.27 | 0.36 | 0.74 | 0.59 | 1.11 | 1.88 | 2.79 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 4.98 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CD79A | ENSG00000105369 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.32 | 5.41 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SIGLEC6 | ENSG00000105492 | 0.00 | 1.53 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 1.66 | 0.77 | 1.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 2.07 | 2.58 | 0.00 | 0.25 | 0.57 | 0.56 | 0.20 | 0.78 | 0.86 | 4.27 | 0.81 | 0.00 | 0.41 | 0.00 | 2.44 | 0.00 | 0.00 |
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