Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GGT5 | ENSG00000099998 | 0.00 | 0.00 | 0.10 | 1.46 | 0.00 | 1.29 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.28 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.56 | 0.61 | 0.78 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| PTAFR | ENSG00000169403 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| APLNR | ENSG00000134817 | 1.11 | 0.76 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 1.13 | 2.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CXCR1 | ENSG00000163464 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.56 | 1.07 | 1.23 | 0.25 | 1.15 | 0.00 | 0.20 | 0.78 | 0.43 | 2.13 | 1.08 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| NPY1R | ENSG00000164128 | 0.00 | 1.27 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 1.54 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 2.07 | 2.36 | 0.00 | 0.00 | 0.57 | 0.56 | 0.20 | 0.78 | 0.00 | 3.55 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| OPRK1 | ENSG00000082556 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 1.29 | 2.70 | 0.00 | 0.77 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 1.51 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 3.08 | 1.90 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AGTR2 | ENSG00000180772 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 5.41 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.94 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.55 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| HTR7 | ENSG00000148680 | 0.00 | 0.76 | 0.00 | 1.09 | 0.00 | 1.94 | 0.00 | 0.55 | 1.03 | 1.20 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 1.11 | 1.32 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| P2RY11 | ENSG00000244165 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.00 | 0.00 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ADGRL4 | ENSG00000162618 | 1.11 | 2.29 | 0.52 | 1.09 | 0.00 | 1.61 | 0.00 | 0.55 | 1.55 | 2.19 | 0.00 | 0.54 | 0.71 | 1.47 | 0.20 | 2.78 | 5.84 | 4.72 | 1.23 | 0.74 | 1.72 | 0.56 | 0.20 | 0.00 | 1.29 | 6.16 | 3.25 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 1.25 |
| CXCR5 | ENSG00000160683 | 1.11 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| LPAR5 | ENSG00000184574 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 0.27 | 0.69 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| LTB4R | ENSG00000213903 | 0.00 | 0.00 | 0.00 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 0.00 | 0.00 | 0.25 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD19 | ENSG00000177455 | 0.00 | 1.02 | 0.62 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 1.11 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CCR7 | ENSG00000126353 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| ADGRE2 | ENSG00000127507 | 1.11 | 1.27 | 0.72 | 0.36 | 2.86 | 1.29 | 0.00 | 1.10 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.56 | 2.45 | 2.79 | 1.23 | 0.74 | 0.57 | 0.00 | 1.02 | 0.78 | 0.86 | 1.18 | 1.08 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| F2RL3 | ENSG00000127533 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| NMUR1 | ENSG00000171596 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.51 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| NTSR1 | ENSG00000101188 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 1.03 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 1.13 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 2.34 | 1.29 | 1.18 | 0.27 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| CCR4 | ENSG00000183813 | 1.11 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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