Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ADGRF5 | ENSG00000069122 | 0.00 | 1.78 | 0.83 | 1.46 | 0.00 | 0.97 | 5.41 | 0.55 | 2.32 | 1.59 | 0.00 | 0.54 | 0.71 | 0.74 | 0.78 | 0.83 | 1.32 | 3.00 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 7.11 | 1.36 | 0.00 | 0.20 | 0.83 | 2.66 | 0.00 | 0.00 |
| ABCB1 | ENSG00000085563 | 1.11 | 3.05 | 0.52 | 1.09 | 0.00 | 0.97 | 2.70 | 2.76 | 2.32 | 3.19 | 0.00 | 1.63 | 0.36 | 0.00 | 0.78 | 2.22 | 6.78 | 6.44 | 0.00 | 1.23 | 2.30 | 0.00 | 1.02 | 0.78 | 0.00 | 7.35 | 5.42 | 0.00 | 0.00 | 0.00 | 3.55 | 1.82 | 0.00 |
| P2RY8 | ENSG00000182162 | 0.00 | 0.00 | 0.41 | 0.36 | 0.00 | 0.65 | 16.22 | 1.10 | 0.77 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 1.88 | 2.58 | 0.00 | 0.25 | 1.15 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CD1C | ENSG00000158481 | 1.11 | 0.51 | 0.62 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.94 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.81 | 0.00 | 0.43 | 4.98 | 2.98 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CD1B | ENSG00000158485 | 0.00 | 0.51 | 0.72 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 1.11 | 1.88 | 2.79 | 0.00 | 0.74 | 0.00 | 0.56 | 0.41 | 0.78 | 0.00 | 3.08 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| CADM3 | ENSG00000162706 | 1.11 | 1.02 | 0.21 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.56 | 1.88 | 3.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 3.32 | 2.17 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| FCGR2A | ENSG00000143226 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 1.25 |
| DDR2 | ENSG00000162733 | 0.00 | 2.29 | 1.03 | 1.82 | 0.00 | 1.94 | 2.70 | 0.55 | 1.29 | 1.59 | 0.00 | 0.54 | 0.71 | 0.74 | 0.20 | 0.56 | 2.45 | 2.79 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 0.43 | 1.42 | 1.90 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| CD34 | ENSG00000174059 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.00 | 1.69 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC29A2 | ENSG00000174669 | 0.00 | 2.04 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ESAM | ENSG00000149564 | 1.11 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 1.50 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CD27 | ENSG00000139193 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ITGB7 | ENSG00000139626 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.19 | 0.43 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ITGA11 | ENSG00000137809 | 0.00 | 2.29 | 0.62 | 1.09 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.81 | 0.36 | 0.74 | 0.20 | 0.56 | 1.32 | 2.15 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 2.00 | 1.82 | 0.00 |
| NPTN | ENSG00000156642 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC5A7 | ENSG00000115665 | 0.00 | 1.27 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 2.58 | 1.79 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 2.26 | 1.72 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 3.79 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| CD28 | ENSG00000178562 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SIRPB1 | ENSG00000101307 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.03 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.94 | 1.50 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.86 | 3.79 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SLC23A2 | ENSG00000089057 | 1.11 | 0.76 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.56 | 0.94 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.81 | 0.69 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| CHL1 | ENSG00000134121 | 2.22 | 2.80 | 0.52 | 1.46 | 2.86 | 2.90 | 0.00 | 2.76 | 1.80 | 2.39 | 0.00 | 0.81 | 0.71 | 3.68 | 0.00 | 3.06 | 7.34 | 3.65 | 0.00 | 0.25 | 0.57 | 0.00 | 0.81 | 1.56 | 2.16 | 8.29 | 3.25 | 0.00 | 0.00 | 0.83 | 4.21 | 0.00 | 0.00 |
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