Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SIGLEC10 | ENSG00000142512 | 0.00 | 2.54 | 0.52 | 1.82 | 5.71 | 0.97 | 0.00 | 1.10 | 1.03 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 2.64 | 2.79 | 2.47 | 0.98 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 5.45 | 1.08 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| KIR3DL1 | ENSG00000167633 | 0.00 | 1.02 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 2.26 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 4.74 | 1.63 | 0.69 | 0.20 | 0.00 | 0.89 | 3.64 | 0.00 |
| ANTXR1 | ENSG00000169604 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.39 | 0.28 | 2.64 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IL1R2 | ENSG00000115590 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| DPP4 | ENSG00000197635 | 0.00 | 1.78 | 0.72 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 1.59 | 0.00 | 0.54 | 0.00 | 0.00 | 0.59 | 0.28 | 1.88 | 3.00 | 0.00 | 1.72 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.66 | 0.81 | 0.69 | 0.00 | 0.00 | 1.33 | 1.82 | 1.25 |
| IFNAR2 | ENSG00000159110 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.81 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| IL2RB | ENSG00000100385 | 0.00 | 0.51 | 0.52 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.83 | 0.75 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 1.29 | 2.61 | 0.27 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ALCAM | ENSG00000170017 | 0.00 | 0.76 | 0.52 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 1.39 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.00 | 1.32 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 2.13 | 1.08 | 0.00 | 0.20 | 0.00 | 1.55 | 5.45 | 0.00 |
| CD200R1 | ENSG00000163606 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 1.32 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 2.37 | 0.00 | 0.00 | 0.20 | 0.83 | 0.22 | 0.00 | 0.00 |
| MME | ENSG00000196549 | 2.22 | 1.78 | 0.31 | 0.73 | 2.86 | 1.94 | 5.41 | 1.66 | 0.26 | 3.19 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 1.39 | 2.45 | 3.65 | 0.00 | 1.72 | 0.00 | 0.00 | 0.41 | 1.56 | 1.29 | 4.98 | 1.63 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| MUC4 | ENSG00000145113 | 5.56 | 4.07 | 3.62 | 13.87 | 0.00 | 2.90 | 2.70 | 7.73 | 1.29 | 2.39 | 0.00 | 1.36 | 1.42 | 0.74 | 0.59 | 3.33 | 2.64 | 5.58 | 2.47 | 1.96 | 0.57 | 0.00 | 0.20 | 3.13 | 0.86 | 9.72 | 2.44 | 0.00 | 0.00 | 0.83 | 9.53 | 0.00 | 2.50 |
| TLR1 | ENSG00000174125 | 0.00 | 0.76 | 0.21 | 0.36 | 2.86 | 0.32 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.27 | 1.07 | 0.00 | 0.59 | 0.00 | 1.13 | 0.86 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 2.84 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| PARM1 | ENSG00000169116 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 1.66 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.19 | 0.00 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 4.50 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| BTN3A3 | ENSG00000111801 | 0.00 | 1.53 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.71 | 0.54 | 0.00 | 0.41 | 0.00 | 1.11 | 1.82 | 0.00 |
| TNFRSF21 | ENSG00000146072 | 1.11 | 0.76 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 1.39 | 0.38 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.81 | 0.00 | 1.29 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| NTRK2 | ENSG00000148053 | 1.11 | 1.53 | 0.83 | 0.36 | 0.00 | 1.61 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 1.67 | 3.39 | 1.50 | 1.23 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 1.63 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| MS4A1 | ENSG00000156738 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.00 | 2.07 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FOLR1 | ENSG00000110195 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ITGA7 | ENSG00000135424 | 0.00 | 1.53 | 0.41 | 1.46 | 0.00 | 1.94 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 1.67 | 1.32 | 2.58 | 0.00 | 0.49 | 0.57 | 0.00 | 0.61 | 0.78 | 0.00 | 4.03 | 0.54 | 1.39 | 0.41 | 0.00 | 2.00 | 1.82 | 0.00 |
| P2RX7 | ENSG00000089041 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 1.13 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.86 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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