Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| JAM2 | ENSG00000154721 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.94 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| IL7R | ENSG00000168685 | 1.11 | 1.27 | 0.52 | 0.00 | 0.00 | 1.61 | 0.00 | 0.55 | 0.52 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 2.82 | 4.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 8.06 | 1.90 | 0.00 | 0.61 | 0.00 | 1.77 | 0.00 | 0.00 |
| L1CAM | ENSG00000198910 | 1.11 | 1.27 | 0.93 | 1.09 | 0.00 | 0.32 | 0.00 | 1.10 | 2.06 | 1.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.78 | 1.11 | 5.84 | 2.36 | 0.00 | 0.98 | 1.15 | 0.00 | 1.02 | 1.56 | 0.86 | 2.84 | 1.36 | 0.00 | 0.00 | 0.00 | 2.88 | 1.82 | 0.00 |
| SLC46A1 | ENSG00000076351 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.56 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC6A6 | ENSG00000131389 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.00 | 0.56 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| CALCRL | ENSG00000064989 | 1.11 | 1.78 | 0.52 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 2.82 | 1.50 | 0.00 | 0.98 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 4.27 | 1.63 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CD48 | ENSG00000117091 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CD163 | ENSG00000177575 | 0.00 | 2.80 | 0.31 | 1.82 | 0.00 | 1.94 | 0.00 | 1.66 | 1.55 | 3.19 | 1.54 | 0.27 | 1.07 | 0.00 | 0.59 | 0.28 | 4.52 | 5.36 | 0.00 | 2.21 | 0.57 | 0.56 | 0.41 | 2.34 | 0.86 | 17.54 | 3.52 | 0.00 | 0.41 | 0.00 | 1.77 | 0.00 | 1.25 |
| PTPRM | ENSG00000173482 | 0.00 | 3.31 | 0.62 | 1.82 | 0.00 | 2.26 | 0.00 | 2.76 | 1.03 | 3.39 | 0.00 | 1.08 | 1.42 | 0.00 | 0.98 | 2.22 | 2.07 | 3.43 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 4.69 | 0.86 | 1.66 | 3.79 | 0.00 | 0.00 | 0.83 | 3.10 | 1.82 | 0.00 |
| ITGA4 | ENSG00000115232 | 1.11 | 3.31 | 0.41 | 2.19 | 0.00 | 1.61 | 2.70 | 1.10 | 0.77 | 2.39 | 0.00 | 0.54 | 0.36 | 0.74 | 0.78 | 0.56 | 5.46 | 2.58 | 0.00 | 0.98 | 0.57 | 0.00 | 0.41 | 2.34 | 0.43 | 8.77 | 1.63 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| ITGB5 | ENSG00000082781 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.52 | 0.20 | 0.00 | 0.54 | 1.78 | 0.00 | 0.00 | 1.94 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| ATP1B3 | ENSG00000069849 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NLGN1 | ENSG00000169760 | 2.22 | 2.54 | 0.52 | 2.19 | 0.00 | 1.29 | 2.70 | 4.42 | 0.26 | 2.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 3.33 | 3.77 | 6.22 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 2.37 | 2.44 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| EFNB1 | ENSG00000090776 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 5.41 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CSPG4 | ENSG00000173546 | 2.22 | 3.31 | 0.52 | 1.09 | 0.00 | 0.32 | 2.70 | 2.21 | 0.52 | 1.59 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 1.39 | 2.45 | 3.00 | 1.23 | 0.98 | 1.15 | 0.00 | 0.41 | 0.78 | 0.86 | 3.08 | 2.98 | 0.00 | 0.20 | 0.00 | 3.10 | 0.00 | 1.25 |
| ABCC1 | ENSG00000103222 | 1.11 | 2.04 | 0.62 | 1.09 | 2.86 | 1.29 | 5.41 | 0.00 | 1.55 | 0.60 | 0.00 | 0.27 | 1.07 | 0.00 | 0.20 | 0.83 | 1.88 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 3.91 | 0.43 | 2.61 | 0.81 | 0.69 | 0.00 | 0.83 | 3.33 | 1.82 | 0.00 |
| CD47 | ENSG00000196776 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| THY1 | ENSG00000154096 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DPEP1 | ENSG00000015413 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.77 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 1.07 | 0.00 | 0.00 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| S1PR1 | ENSG00000170989 | 0.00 | 1.78 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.88 | 1.93 | 0.00 | 1.23 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 2.13 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
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