Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SDC4 | ENSG00000124145 | 1.11 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| PIGT | ENSG00000124155 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SV2A | ENSG00000159164 | 0.00 | 1.27 | 0.62 | 0.36 | 0.00 | 1.61 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.56 | 2.07 | 1.29 | 0.00 | 0.49 | 0.57 | 0.00 | 0.61 | 0.78 | 0.00 | 1.42 | 2.17 | 0.00 | 0.00 | 0.00 | 3.33 | 0.00 | 0.00 |
| STX1A | ENSG00000106089 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CD46 | ENSG00000117335 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.83 | 0.56 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.20 | 0.83 | 0.00 | 0.00 | 0.00 |
| SLC41A1 | ENSG00000133065 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CD276 | ENSG00000103855 | 1.11 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 3.08 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| SULF2 | ENSG00000196562 | 2.22 | 1.78 | 0.52 | 0.73 | 0.00 | 0.65 | 2.70 | 0.00 | 2.06 | 0.80 | 1.54 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 3.01 | 1.50 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 3.13 | 0.00 | 2.84 | 0.81 | 0.00 | 0.20 | 0.00 | 1.11 | 1.82 | 1.25 |
| CX3CL1 | ENSG00000006210 | 0.00 | 1.53 | 0.10 | 1.09 | 0.00 | 0.65 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OPN1SW | ENSG00000128617 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CALU | ENSG00000128595 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SMO | ENSG00000128602 | 1.11 | 1.78 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 2.07 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 1.90 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ERMAP | ENSG00000164010 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.56 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| P3H1 | ENSG00000117385 | 0.00 | 2.04 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.56 | 1.32 | 2.15 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLAMF6 | ENSG00000162739 | 1.11 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.77 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 2.36 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| JAG1 | ENSG00000101384 | 0.00 | 2.80 | 0.52 | 1.82 | 0.00 | 1.94 | 0.00 | 1.10 | 0.77 | 1.59 | 0.00 | 0.27 | 1.78 | 0.74 | 0.39 | 0.00 | 1.88 | 1.50 | 1.23 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 2.37 | 1.63 | 0.00 | 0.00 | 0.83 | 3.99 | 1.82 | 0.00 |
| DPP6 | ENSG00000130226 | 0.00 | 1.02 | 0.72 | 0.73 | 0.00 | 1.61 | 0.00 | 3.87 | 0.77 | 2.59 | 0.00 | 0.27 | 1.42 | 0.00 | 0.00 | 1.67 | 4.52 | 6.87 | 0.00 | 0.74 | 1.15 | 0.56 | 0.61 | 0.78 | 0.43 | 4.03 | 1.63 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| RHBDL2 | ENSG00000158315 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SLC19A1 | ENSG00000173638 | 0.00 | 1.02 | 0.00 | 0.73 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.86 | 0.71 | 0.00 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 1.25 |
| PRSS8 | ENSG00000052344 | 1.11 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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