Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KIAA1161 | ENSG00000164976 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.59 | 0.28 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| RTN4R | ENSG00000040608 | 1.11 | 0.25 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ABCC5 | ENSG00000114770 | 0.00 | 4.83 | 0.62 | 0.73 | 0.00 | 0.65 | 2.70 | 2.21 | 0.77 | 1.79 | 0.00 | 0.54 | 1.78 | 0.00 | 0.00 | 0.56 | 1.69 | 2.79 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 2.34 | 0.00 | 2.37 | 0.81 | 0.00 | 0.41 | 0.00 | 1.11 | 0.00 | 0.00 |
| SEZ6L2 | ENSG00000174938 | 1.11 | 1.78 | 0.62 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 1.55 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.59 | 1.39 | 1.51 | 2.58 | 0.00 | 0.98 | 0.57 | 0.00 | 0.20 | 2.34 | 0.43 | 3.32 | 0.81 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| ATP13A3 | ENSG00000133657 | 0.00 | 3.05 | 0.52 | 0.00 | 2.86 | 0.00 | 0.00 | 1.10 | 0.77 | 1.99 | 0.00 | 0.81 | 0.36 | 0.74 | 0.39 | 0.83 | 1.51 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.37 | 1.36 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| ADCY3 | ENSG00000138031 | 0.00 | 1.02 | 0.41 | 1.09 | 0.00 | 0.65 | 2.70 | 0.55 | 1.29 | 1.00 | 0.00 | 0.27 | 1.42 | 0.74 | 0.20 | 1.67 | 0.75 | 1.72 | 0.00 | 1.47 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 1.90 | 0.00 | 0.00 | 0.83 | 2.00 | 0.00 | 0.00 |
| ATRAID | ENSG00000138085 | 0.00 | 0.00 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC5A6 | ENSG00000138074 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.54 | 0.71 | 0.74 | 0.00 | 0.00 | 0.75 | 1.50 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MTM1 | ENSG00000171100 | 0.00 | 1.27 | 0.93 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 1.54 | 0.00 | 0.36 | 0.74 | 0.20 | 0.83 | 1.69 | 0.86 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| LRRC26 | ENSG00000184709 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OXER1 | ENSG00000162881 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.54 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| CNTFR | ENSG00000122756 | 1.11 | 0.25 | 0.21 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.24 | 0.54 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| IL11RA | ENSG00000137070 | 0.00 | 0.25 | 0.52 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| KCNS3 | ENSG00000170745 | 0.00 | 1.78 | 0.31 | 0.36 | 0.00 | 1.29 | 2.70 | 0.55 | 0.77 | 1.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.39 | 0.83 | 1.51 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.66 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| HSPD1 | ENSG00000144381 | 0.00 | 1.02 | 0.62 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 1.54 | 0.27 | 1.07 | 0.00 | 0.20 | 0.56 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 0.71 | 1.08 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| GPR146 | ENSG00000164849 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| OPRL1 | ENSG00000125510 | 1.11 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 2.21 | 0.52 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.69 | 1.72 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.54 | 0.00 | 0.20 | 0.83 | 0.67 | 0.00 | 0.00 |
| ADGRG2 | ENSG00000173698 | 0.00 | 2.04 | 0.72 | 1.09 | 2.86 | 1.29 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.56 | 2.26 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| SLC13A3 | ENSG00000158296 | 0.00 | 0.51 | 0.41 | 0.00 | 0.00 | 1.61 | 0.00 | 0.00 | 0.77 | 1.99 | 0.00 | 0.27 | 1.42 | 0.00 | 0.20 | 0.83 | 1.13 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 3.13 | 0.43 | 2.13 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ANGPT1 | ENSG00000154188 | 0.00 | 0.76 | 0.62 | 0.73 | 2.86 | 0.00 | 0.00 | 2.76 | 0.26 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 1.88 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 7.11 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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