Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TRIM66 | ENSG00000166436 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 1.94 | 0.00 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PHF21A | ENSG00000135365 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.77 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 0.56 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| MTA2 | ENSG00000149480 | 0.00 | 1.78 | 0.31 | 0.36 | 0.00 | 0.97 | 2.70 | 1.10 | 0.52 | 1.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.59 | 0.56 | 0.94 | 0.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| DPF2 | ENSG00000133884 | 0.00 | 1.78 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.56 | 1.32 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KAT5 | ENSG00000172977 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 1.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| RSF1 | ENSG00000048649 | 1.11 | 3.56 | 0.41 | 1.09 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.54 | 0.71 | 0.74 | 0.39 | 1.11 | 1.88 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 2.34 | 0.86 | 3.79 | 1.90 | 0.69 | 0.20 | 0.00 | 2.22 | 1.82 | 0.00 |
| KDM4D | ENSG00000186280 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.52 | 0.20 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.28 | 1.13 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PRDM10 | ENSG00000170325 | 1.11 | 1.78 | 1.14 | 0.36 | 0.00 | 1.61 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.39 | 0.83 | 2.45 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.13 | 0.81 | 0.00 | 0.20 | 0.00 | 2.66 | 0.00 | 0.00 |
| ING4 | ENSG00000111653 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CBX5 | ENSG00000094916 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.75 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 1.82 | 1.25 |
| SMARCC2 | ENSG00000139613 | 0.00 | 3.56 | 0.83 | 1.09 | 0.00 | 0.97 | 0.00 | 1.66 | 1.03 | 1.00 | 0.00 | 1.08 | 1.42 | 0.00 | 0.20 | 1.11 | 1.88 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 3.13 | 0.43 | 2.84 | 0.81 | 0.00 | 0.41 | 0.00 | 2.66 | 1.82 | 0.00 |
| BAZ2A | ENSG00000076108 | 0.00 | 4.07 | 1.14 | 0.73 | 0.00 | 0.65 | 2.70 | 2.21 | 0.26 | 0.80 | 0.00 | 0.27 | 1.42 | 0.00 | 0.20 | 1.67 | 0.94 | 1.72 | 1.23 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 3.08 | 1.08 | 0.69 | 0.00 | 0.00 | 2.44 | 0.00 | 1.25 |
| PRDM4 | ENSG00000110851 | 1.11 | 2.29 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.54 | 0.00 | 1.47 | 0.00 | 0.56 | 0.94 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 1.25 |
| SETD1B | ENSG00000139718 | 2.22 | 0.00 | 0.52 | 1.82 | 0.00 | 1.61 | 8.11 | 1.10 | 0.00 | 0.00 | 1.54 | 0.54 | 0.00 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 7.10 | 0.00 | 0.00 |
| SETD8 | ENSG00000183955 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RNF17 | ENSG00000132972 | 1.11 | 3.82 | 0.52 | 2.55 | 0.00 | 1.94 | 0.00 | 2.76 | 2.06 | 1.79 | 0.00 | 0.27 | 1.07 | 0.00 | 0.78 | 1.39 | 2.82 | 2.36 | 1.23 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 9.24 | 2.17 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| PHF11 | ENSG00000136147 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TDRD3 | ENSG00000083544 | 0.00 | 2.29 | 0.10 | 0.73 | 0.00 | 1.94 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.54 | 1.07 | 0.00 | 0.39 | 0.28 | 1.69 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.18 | 1.63 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| G2E3 | ENSG00000092140 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.60 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.83 | 0.75 | 1.07 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| BAZ1A | ENSG00000198604 | 1.11 | 2.54 | 0.93 | 1.46 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 2.58 | 0.00 | 0.98 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
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