Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| CHD7 | ENSG00000171316 | 1.11 | 6.36 | 1.65 | 5.47 | 8.57 | 2.26 | 2.70 | 2.21 | 1.03 | 3.78 | 0.00 | 2.44 | 0.71 | 0.00 | 0.20 | 1.67 | 5.46 | 7.51 | 0.00 | 2.21 | 0.00 | 0.00 | 1.02 | 1.56 | 2.16 | 6.16 | 3.52 | 0.00 | 0.00 | 0.83 | 5.99 | 1.82 | 0.00 |
| SMARCA2 | ENSG00000080503 | 1.11 | 5.34 | 0.62 | 1.46 | 0.00 | 2.26 | 2.70 | 1.66 | 1.29 | 2.19 | 0.00 | 1.08 | 0.36 | 0.74 | 0.20 | 1.39 | 3.01 | 2.15 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 0.78 | 0.86 | 1.90 | 2.98 | 0.00 | 0.00 | 0.00 | 3.77 | 0.00 | 0.00 |
| PHF6 | ENSG00000156531 | 1.11 | 1.78 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 2.21 | 0.39 | 0.28 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| PRDM16 | ENSG00000142611 | 0.00 | 3.31 | 0.41 | 2.19 | 0.00 | 0.65 | 2.70 | 1.66 | 0.77 | 1.59 | 1.54 | 0.27 | 0.71 | 2.21 | 0.20 | 1.67 | 2.64 | 3.00 | 0.00 | 1.23 | 0.00 | 0.00 | 0.61 | 0.00 | 0.86 | 4.74 | 1.90 | 0.00 | 0.61 | 0.00 | 2.66 | 0.00 | 0.00 |
| PHF13 | ENSG00000116273 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| RERE | ENSG00000142599 | 1.11 | 2.04 | 0.83 | 0.73 | 0.00 | 0.32 | 0.00 | 1.66 | 1.55 | 0.80 | 0.00 | 0.27 | 2.49 | 0.00 | 0.98 | 0.56 | 1.13 | 1.50 | 0.00 | 1.23 | 1.15 | 0.00 | 0.61 | 0.78 | 0.43 | 4.50 | 2.44 | 0.69 | 0.41 | 0.00 | 4.43 | 1.82 | 1.25 |
| PRDM2 | ENSG00000116731 | 0.00 | 3.05 | 0.31 | 0.73 | 0.00 | 0.97 | 2.70 | 0.55 | 0.00 | 1.99 | 1.54 | 0.27 | 1.42 | 0.74 | 0.39 | 1.11 | 3.58 | 2.58 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 2.61 | 1.36 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 1.25 |
| SCMH1 | ENSG00000010803 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| MTF2 | ENSG00000143033 | 1.11 | 1.27 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.81 | 1.39 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| TRIM33 | ENSG00000197323 | 1.11 | 1.27 | 0.52 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.54 | 1.07 | 0.74 | 0.20 | 0.00 | 1.13 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 0.47 | 1.36 | 0.00 | 0.20 | 0.00 | 1.77 | 1.82 | 0.00 |
| PYGO2 | ENSG00000163348 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 1.11 | 0.75 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ARID4B | ENSG00000054267 | 0.00 | 2.80 | 1.55 | 0.73 | 2.86 | 0.65 | 0.00 | 2.21 | 0.26 | 1.20 | 0.00 | 0.00 | 1.07 | 0.00 | 0.59 | 0.28 | 1.69 | 2.58 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 1.42 | 2.17 | 0.69 | 0.00 | 0.00 | 5.99 | 0.00 | 0.00 |
| SMYD3 | ENSG00000185420 | 0.00 | 0.76 | 0.72 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.69 | 1.29 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TAF3 | ENSG00000165632 | 2.22 | 1.53 | 0.21 | 0.36 | 0.00 | 1.29 | 0.00 | 1.66 | 0.52 | 0.60 | 0.00 | 0.27 | 0.71 | 1.47 | 0.20 | 0.83 | 2.45 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.54 | 0.69 | 0.00 | 0.83 | 2.00 | 0.00 | 0.00 |
| JMJD1C | ENSG00000171988 | 1.11 | 4.07 | 1.34 | 2.92 | 0.00 | 1.29 | 5.41 | 1.10 | 0.77 | 4.18 | 1.54 | 0.81 | 2.49 | 0.74 | 0.20 | 1.67 | 3.58 | 3.86 | 0.00 | 1.96 | 0.00 | 0.00 | 0.41 | 3.91 | 0.00 | 2.61 | 2.17 | 0.00 | 0.81 | 0.00 | 5.10 | 0.00 | 0.00 |
| KAT6B | ENSG00000156650 | 0.00 | 1.78 | 1.45 | 2.19 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.20 | 0.00 | 0.81 | 0.71 | 0.74 | 1.96 | 0.56 | 2.45 | 1.72 | 1.23 | 1.96 | 0.57 | 0.00 | 0.81 | 0.78 | 0.00 | 2.37 | 0.54 | 0.00 | 0.41 | 0.00 | 2.88 | 0.00 | 0.00 |
| SMNDC1 | ENSG00000119953 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TDRD1 | ENSG00000095627 | 0.00 | 1.53 | 0.41 | 2.55 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 1.39 | 0.00 | 0.54 | 1.78 | 0.00 | 0.20 | 1.67 | 2.45 | 1.72 | 0.00 | 1.47 | 0.57 | 0.00 | 0.61 | 0.78 | 0.86 | 4.98 | 1.63 | 0.00 | 0.00 | 0.00 | 2.66 | 1.82 | 0.00 |
| PWWP2B | ENSG00000171813 | 1.11 | 1.02 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.38 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PHRF1 | ENSG00000070047 | 1.11 | 3.56 | 0.41 | 2.55 | 0.00 | 1.29 | 0.00 | 1.10 | 1.03 | 3.19 | 1.54 | 0.00 | 1.07 | 0.00 | 0.00 | 1.67 | 1.51 | 1.50 | 3.70 | 0.98 | 0.00 | 0.56 | 0.20 | 1.56 | 2.16 | 2.37 | 1.63 | 0.00 | 0.00 | 0.00 | 3.33 | 1.82 | 0.00 |
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