Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KMT2D | ENSG00000167548 | 3.33 | 26.46 | 2.48 | 12.41 | 2.86 | 3.87 | 32.43 | 10.50 | 1.55 | 14.94 | 3.08 | 2.71 | 4.98 | 0.00 | 1.76 | 4.44 | 6.40 | 21.03 | 0.00 | 1.47 | 3.45 | 0.56 | 5.50 | 2.34 | 1.72 | 10.90 | 5.69 | 1.39 | 0.41 | 0.83 | 19.51 | 7.27 | 1.25 |
| ARID4A | ENSG00000032219 | 1.11 | 3.56 | 0.41 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 1.59 | 0.00 | 0.00 | 1.07 | 0.74 | 0.20 | 0.28 | 2.07 | 2.36 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.37 | 1.63 | 0.69 | 0.00 | 0.00 | 2.88 | 1.82 | 0.00 |
| NCOA1 | ENSG00000084676 | 1.11 | 3.82 | 0.52 | 1.09 | 0.00 | 1.29 | 0.00 | 2.21 | 0.52 | 1.00 | 0.00 | 0.27 | 1.07 | 0.00 | 0.00 | 0.56 | 2.26 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.37 | 1.36 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| ZGPAT | ENSG00000197114 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.54 | 1.07 | 0.00 | 0.00 | 0.28 | 0.94 | 1.29 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.81 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| PHF20L1 | ENSG00000129292 | 2.22 | 2.54 | 1.03 | 0.73 | 2.86 | 1.61 | 0.00 | 0.55 | 0.52 | 1.39 | 0.00 | 0.54 | 2.14 | 0.74 | 0.20 | 0.28 | 2.45 | 2.36 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 1.29 | 1.66 | 0.81 | 1.39 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| LBR | ENSG00000143815 | 1.11 | 1.27 | 0.52 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 1.42 | 0.74 | 0.20 | 1.39 | 0.75 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AIRE | ENSG00000160224 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.56 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.27 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PHF7 | ENSG00000010318 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| JADE1 | ENSG00000077684 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 1.11 | 1.13 | 0.21 | 1.23 | 0.25 | 0.00 | 0.56 | 0.20 | 0.00 | 0.43 | 1.42 | 0.27 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| FMR1 | ENSG00000102081 | 0.00 | 0.25 | 0.83 | 1.09 | 0.00 | 0.97 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.56 | 2.07 | 3.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.47 | 1.63 | 0.00 | 0.20 | 0.00 | 2.44 | 0.00 | 0.00 |
| MLLT10 | ENSG00000078403 | 1.11 | 1.02 | 0.72 | 1.46 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 1.20 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.83 | 2.07 | 3.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 1.56 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| SMYD4 | ENSG00000186532 | 0.00 | 1.53 | 0.21 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ZMYND11 | ENSG00000015171 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.51 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| AKAP1 | ENSG00000121057 | 1.11 | 1.27 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 2.21 | 0.26 | 1.20 | 0.00 | 0.54 | 0.36 | 0.74 | 0.00 | 0.56 | 1.69 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.78 | 0.00 | 2.61 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PCMT1 | ENSG00000120265 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SPIN3 | ENSG00000204271 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.32 | 2.70 | 0.00 | 0.52 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TDRKH | ENSG00000182134 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.29 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| METTL21A | ENSG00000144401 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PRDM11 | ENSG00000019485 | 0.00 | 1.53 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 1.32 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 1.25 |
| TDRD9 | ENSG00000156414 | 0.00 | 1.02 | 0.52 | 0.00 | 2.86 | 0.32 | 0.00 | 1.66 | 1.03 | 0.40 | 0.00 | 0.81 | 0.00 | 0.74 | 0.39 | 1.11 | 1.51 | 1.29 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 2.34 | 0.86 | 1.90 | 0.27 | 0.00 | 0.00 | 0.83 | 1.55 | 1.82 | 0.00 |
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