Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
| Showing page 291 |
first page | previous page | next page | last page |
| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| NR5A1 | ENSG00000136931 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 1.61 | 0.00 | 0.00 | 0.00 | 0.00 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NR6A1 | ENSG00000148200 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CDK9 | ENSG00000136807 | 0.00 | 1.02 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ENDOG | ENSG00000167136 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| LAMC3 | ENSG00000050555 | 1.11 | 2.29 | 0.52 | 1.46 | 0.00 | 3.23 | 0.00 | 1.10 | 1.03 | 1.20 | 0.00 | 1.36 | 0.71 | 0.00 | 0.20 | 1.11 | 3.58 | 3.43 | 0.00 | 1.47 | 0.00 | 0.56 | 0.00 | 0.78 | 0.43 | 1.66 | 1.90 | 0.00 | 0.41 | 0.00 | 3.99 | 0.00 | 0.00 |
| WDR5 | ENSG00000196363 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| RXRA | ENSG00000186350 | 0.00 | 5.34 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 1.03 | 0.40 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 1.11 | 0.19 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PMPCA | ENSG00000165688 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.00 | 2.70 | 1.10 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| EGFL7 | ENSG00000172889 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PRPS2 | ENSG00000101911 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.54 | 0.36 | 0.74 | 0.20 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TMSB4X | ENSG00000205542 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 16.22 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| EGFL6 | ENSG00000198759 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.65 | 2.70 | 0.55 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.69 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CA5B | ENSG00000169239 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| SMS | ENSG00000102172 | 0.00 | 0.25 | 0.00 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.81 | 0.00 | 0.74 | 0.00 | 0.00 | 0.56 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PDK3 | ENSG00000067992 | 1.11 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 1.47 | 0.20 | 0.56 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.20 | 0.00 | 1.55 | 1.82 | 0.00 |
| NR0B1 | ENSG00000169297 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 2.26 | 5.41 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.11 | 1.88 | 1.29 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 2.34 | 0.86 | 0.00 | 0.54 | 0.69 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| OTC | ENSG00000036473 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| DDX3X | ENSG00000215301 | 0.00 | 3.31 | 0.41 | 3.65 | 0.00 | 0.00 | 8.11 | 1.10 | 0.26 | 1.39 | 0.00 | 0.81 | 1.07 | 0.74 | 0.39 | 0.00 | 0.94 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.45 | 1.36 | 0.69 | 0.00 | 0.00 | 4.21 | 0.00 | 0.00 |
| DUSP21 | ENSG00000189037 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RBM10 | ENSG00000182872 | 1.11 | 3.56 | 0.31 | 0.73 | 0.00 | 2.26 | 2.70 | 1.66 | 0.26 | 0.40 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 1.11 | 6.40 | 1.50 | 0.00 | 0.00 | 1.72 | 0.00 | 0.00 | 2.34 | 0.43 | 0.95 | 0.00 | 0.69 | 0.00 | 0.00 | 3.33 | 0.00 | 0.00 |
|
Showing page 291 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.