Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| KLHL9 | ENSG00000198642 | 0.00 | 1.27 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.83 | 1.13 | 1.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| MTAP | ENSG00000099810 | 1.11 | 0.00 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| TAF1L | ENSG00000122728 | 1.11 | 4.83 | 1.65 | 3.28 | 0.00 | 5.48 | 0.00 | 3.87 | 3.61 | 4.18 | 0.00 | 1.90 | 0.36 | 0.00 | 0.78 | 2.50 | 9.60 | 8.15 | 0.00 | 2.45 | 0.00 | 0.00 | 1.43 | 3.13 | 1.72 | 10.66 | 5.96 | 0.69 | 0.41 | 1.65 | 5.54 | 0.00 | 0.00 |
| DNAJA1 | ENSG00000086061 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PRSS3P4 | ENSG00000204982 | |||||||||||||||||||||||||||||||||
| CCL27 | ENSG00000213927 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CCL19 | ENSG00000172724 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| VCP | ENSG00000165280 | 0.00 | 1.02 | 0.52 | 1.46 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.94 | 0.21 | 0.00 | 0.98 | 0.00 | 0.56 | 0.20 | 0.00 | 0.43 | 0.47 | 0.54 | 0.00 | 0.41 | 0.00 | 1.77 | 0.00 | 0.00 |
| TESK1 | ENSG00000107140 | 1.11 | 0.76 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PTAR1 | ENSG00000188647 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RORB | ENSG00000198963 | 0.00 | 0.76 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 1.07 | 0.00 | 0.59 | 0.28 | 1.51 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 3.55 | 0.54 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| AGTPBP1 | ENSG00000135049 | 0.00 | 2.04 | 0.62 | 1.46 | 0.00 | 1.29 | 0.00 | 0.00 | 0.52 | 1.99 | 0.00 | 0.81 | 1.07 | 0.00 | 0.00 | 0.28 | 0.94 | 2.36 | 0.00 | 1.23 | 0.00 | 0.56 | 0.00 | 0.78 | 0.43 | 2.13 | 1.36 | 0.00 | 0.00 | 0.83 | 1.33 | 0.00 | 0.00 |
| CTSL3P | ENSG00000188029 | |||||||||||||||||||||||||||||||||
| HABP4 | ENSG00000130956 | 0.00 | 0.25 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TSTD2 | ENSG00000136925 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NR4A3 | ENSG00000119508 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.18 | 1.08 | 0.00 | 0.20 | 0.00 | 1.33 | 1.82 | 0.00 |
| TXN | ENSG00000136810 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| FKBP15 | ENSG00000119321 | 0.00 | 1.27 | 0.52 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.56 | 0.56 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| PRPF4 | ENSG00000136875 | 0.00 | 1.02 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PSMB7 | ENSG00000136930 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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