Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SLC9A3 | ENSG00000066230 | 1.11 | 1.53 | 0.31 | 0.36 | 5.71 | 1.29 | 0.00 | 1.10 | 0.26 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 1.11 | 1.69 | 1.29 | 0.00 | 0.25 | 0.57 | 0.56 | 0.20 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
| OPN3 | ENSG00000054277 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.75 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PLAT | ENSG00000104368 | 0.00 | 1.53 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 1.88 | 0.64 | 1.23 | 0.00 | 0.00 | 0.56 | 0.41 | 0.00 | 0.43 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| TMEM123 | ENSG00000152558 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| CD59 | ENSG00000085063 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PDGFA | ENSG00000197461 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SLC4A11 | ENSG00000088836 | 4.44 | 1.27 | 0.41 | 0.73 | 2.86 | 0.97 | 0.00 | 0.55 | 0.26 | 1.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 2.07 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 2.13 | 3.25 | 0.00 | 0.00 | 0.00 | 3.99 | 0.00 | 0.00 |
| SLC15A1 | ENSG00000088386 | 1.11 | 0.76 | 0.52 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.32 | 1.72 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 3.08 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| IL1RAP | ENSG00000196083 | 0.00 | 1.02 | 0.83 | 1.82 | 0.00 | 0.97 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 1.29 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ATRN | ENSG00000088812 | 0.00 | 1.02 | 0.72 | 1.46 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 1.99 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 1.32 | 1.29 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 1.63 | 0.00 | 0.00 | 0.00 | 2.44 | 1.82 | 0.00 |
| DUSP15 | ENSG00000149599 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| LIFR | ENSG00000113594 | 0.00 | 1.53 | 0.72 | 1.09 | 0.00 | 2.58 | 0.00 | 1.66 | 0.00 | 2.19 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.83 | 1.88 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 3.91 | 0.43 | 7.82 | 1.36 | 0.00 | 0.00 | 0.83 | 2.66 | 0.00 | 0.00 |
| EPHB3 | ENSG00000182580 | 2.22 | 1.78 | 0.72 | 1.46 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 1.94 | 1.88 | 2.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 3.55 | 1.36 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| CLCN2 | ENSG00000114859 | 2.22 | 2.04 | 0.41 | 0.73 | 0.00 | 1.29 | 2.70 | 1.10 | 0.52 | 1.20 | 1.54 | 0.54 | 0.36 | 0.74 | 0.20 | 0.83 | 0.94 | 1.50 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 1.66 | 0.54 | 0.00 | 0.20 | 0.00 | 2.66 | 3.64 | 0.00 |
| IGSF8 | ENSG00000162729 | 0.00 | 0.00 | 0.41 | 1.09 | 0.00 | 0.32 | 2.70 | 0.55 | 0.52 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 1.51 | 1.29 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| GPRC5C | ENSG00000170412 | 0.00 | 0.76 | 0.00 | 0.36 | 0.00 | 1.61 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 1.13 | 2.15 | 2.47 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.43 | 2.37 | 0.81 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| SLCO4A1 | ENSG00000101187 | 0.00 | 1.78 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 1.93 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 3.10 | 1.82 | 0.00 |
| ADCY8 | ENSG00000155897 | 0.00 | 3.56 | 1.24 | 1.82 | 0.00 | 3.87 | 0.00 | 4.42 | 0.77 | 4.78 | 1.54 | 1.36 | 1.42 | 0.00 | 0.20 | 2.50 | 6.21 | 6.65 | 0.00 | 2.94 | 1.15 | 0.00 | 1.02 | 3.13 | 0.00 | 10.66 | 4.07 | 0.00 | 0.00 | 0.00 | 3.55 | 0.00 | 0.00 |
| RXFP4 | ENSG00000173080 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FGFR4 | ENSG00000160867 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 0.65 | 2.70 | 1.10 | 0.77 | 0.80 | 0.00 | 0.81 | 0.71 | 0.00 | 0.20 | 0.83 | 1.69 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 1.25 |
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