Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ADAM3A | ENSG00000197475 | |||||||||||||||||||||||||||||||||
| DKK4 | ENSG00000104371 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MOS | ENSG00000172680 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 1.29 | 2.70 | 0.00 | 0.00 | 1.39 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.51 | 1.07 | 0.00 | 0.49 | 1.15 | 0.00 | 0.20 | 3.13 | 0.00 | 0.24 | 1.36 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CA8 | ENSG00000178538 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.61 | 0.78 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| COPS5 | ENSG00000121022 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 1.66 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| HNF4G | ENSG00000164749 | 0.00 | 1.53 | 0.10 | 0.00 | 0.00 | 0.00 | 8.11 | 1.10 | 0.26 | 1.00 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.56 | 1.32 | 2.36 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 5.69 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CA13 | ENSG00000185015 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.41 | 0.00 | 0.22 | 0.00 | 0.00 |
| CA1 | ENSG00000133742 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 1.13 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CA3 | ENSG00000164879 | 1.11 | 0.51 | 0.21 | 0.00 | 0.00 | 0.65 | 2.70 | 0.55 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.32 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| RIPK2 | ENSG00000104312 | 1.11 | 0.76 | 0.21 | 0.36 | 2.86 | 0.32 | 0.00 | 0.55 | 0.26 | 1.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CCNE2 | ENSG00000175305 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 1.47 | 0.20 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| MATN2 | ENSG00000132561 | 0.00 | 1.53 | 0.62 | 0.73 | 0.00 | 0.65 | 2.70 | 2.21 | 0.00 | 1.39 | 0.00 | 0.27 | 1.07 | 0.00 | 0.98 | 1.11 | 1.51 | 2.58 | 0.00 | 0.74 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AZIN1 | ENSG00000155096 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KLHL38 | ENSG00000175946 | 0.00 | 0.76 | 0.41 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.77 | 0.80 | 0.00 | 0.54 | 0.00 | 0.74 | 0.39 | 0.83 | 2.07 | 1.29 | 1.23 | 0.98 | 1.72 | 0.00 | 0.20 | 0.78 | 0.00 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| NRBP2 | ENSG00000185189 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| PARP10 | ENSG00000178685 | 0.00 | 1.02 | 0.41 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.83 | 0.75 | 0.86 | 0.00 | 0.98 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 0.95 | 1.08 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| INSL6 | ENSG00000120210 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 0.81 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RLN2 | ENSG00000107014 | 0.00 | 0.25 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IL33 | ENSG00000137033 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KDM4C | ENSG00000107077 | 0.00 | 1.53 | 0.62 | 1.09 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 1.11 | 1.69 | 1.50 | 0.00 | 0.49 | 1.15 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 1.36 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
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