Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PMPCB | ENSG00000105819 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.56 | 0.38 | 1.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PSMC2 | ENSG00000161057 | 2.22 | 1.27 | 0.10 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.47 | 0.81 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| LAMB4 | ENSG00000091128 | 1.11 | 2.80 | 1.55 | 1.09 | 0.00 | 2.26 | 0.00 | 2.21 | 1.29 | 3.19 | 0.00 | 1.36 | 1.07 | 0.00 | 0.59 | 1.39 | 6.03 | 4.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.20 | 2.34 | 0.86 | 8.77 | 1.36 | 0.00 | 0.20 | 0.83 | 3.99 | 0.00 | 0.00 |
| LEP | ENSG00000174697 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CEP41 | ENSG00000106477 | 0.00 | 1.53 | 0.10 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 1.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 1.32 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| AKR1B1 | ENSG00000085662 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| AGBL3 | ENSG00000146856 | 0.00 | 0.00 | 0.83 | 0.73 | 0.00 | 1.94 | 2.70 | 1.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 1.11 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| AKR1D1 | ENSG00000122787 | 1.11 | 1.02 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 1.51 | 2.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 3.79 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| PARP12 | ENSG00000059378 | 3.33 | 0.76 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.60 | 0.00 | 1.08 | 0.00 | 0.74 | 0.59 | 0.56 | 0.19 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CASP2 | ENSG00000106144 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.88 | 0.86 | 0.00 | 0.25 | 0.57 | 0.56 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| EZH2 | ENSG00000106462 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.52 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 1.07 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.32 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| DEFA1 | ENSG00000206047 | |||||||||||||||||||||||||||||||||
| OR7E125P | ENSG00000177306 | |||||||||||||||||||||||||||||||||
| TNKS | ENSG00000173273 | 0.00 | 1.53 | 0.31 | 1.09 | 0.00 | 0.97 | 2.70 | 0.55 | 0.52 | 1.00 | 0.00 | 1.08 | 0.36 | 1.47 | 0.20 | 0.83 | 0.94 | 3.22 | 0.00 | 0.74 | 0.00 | 0.56 | 0.41 | 0.78 | 0.00 | 1.42 | 0.54 | 0.69 | 0.00 | 0.00 | 3.10 | 1.82 | 0.00 |
| OR7E8P | ENSG00000177400 | |||||||||||||||||||||||||||||||||
| FGF20 | ENSG00000078579 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.69 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| MTMR7 | ENSG00000003987 | 0.00 | 1.02 | 0.21 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.39 | 1.32 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.90 | 0.54 | 0.69 | 0.00 | 0.83 | 1.77 | 0.00 | 0.00 |
| ATP6V1B2 | ENSG00000147416 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 1.07 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| PBK | ENSG00000168078 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PNOC | ENSG00000168081 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
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