Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PDE7B | ENSG00000171408 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 4.03 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PPIL4 | ENSG00000131013 | 0.00 | 1.78 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 1.36 | 0.00 | 0.74 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| PSMB1 | ENSG00000008018 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PSMG3 | ENSG00000157778 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PMS2 | ENSG00000122512 | 2.22 | 1.78 | 0.41 | 0.00 | 0.00 | 0.65 | 0.00 | 2.21 | 0.00 | 1.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.39 | 0.56 | 1.51 | 1.29 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 2.34 | 0.86 | 2.13 | 0.27 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| EIF2AK1 | ENSG00000086232 | 0.00 | 1.27 | 0.31 | 1.82 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 1.59 | 0.00 | 0.54 | 1.07 | 0.00 | 0.20 | 0.28 | 1.88 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| COL28A1 | ENSG00000215018 | 0.00 | 1.53 | 0.52 | 0.00 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 1.59 | 1.54 | 0.54 | 0.71 | 0.00 | 0.20 | 1.39 | 2.45 | 2.79 | 1.23 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.86 | 7.35 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PRPS1L1 | ENSG00000229937 | 1.11 | 0.76 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.77 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 0.75 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PDE1C | ENSG00000154678 | 0.00 | 2.29 | 0.62 | 2.55 | 0.00 | 1.61 | 0.00 | 0.55 | 0.77 | 2.39 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 1.94 | 3.95 | 5.58 | 1.23 | 1.47 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 9.72 | 1.36 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| NME8 | ENSG00000086288 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.32 | 2.70 | 4.42 | 1.80 | 1.79 | 0.00 | 0.81 | 0.36 | 1.47 | 0.59 | 0.56 | 2.82 | 2.79 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 6.16 | 2.44 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| PSMA2 | ENSG00000106588 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PPIA | ENSG00000196262 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FKBP6 | ENSG00000077800 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 1.03 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 1.51 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 1.56 | 0.43 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LIMK1 | ENSG00000106683 | 0.00 | 1.53 | 0.21 | 1.82 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.54 | 0.36 | 1.47 | 0.78 | 0.56 | 0.38 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| EIF4H | ENSG00000106682 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| STYXL1 | ENSG00000127952 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| YWHAG | ENSG00000170027 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| DBF4 | ENSG00000006634 | 1.11 | 1.78 | 0.00 | 1.09 | 0.00 | 0.32 | 0.00 | 1.66 | 0.26 | 0.40 | 1.54 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.56 | 1.29 | 0.00 | 0.98 | 0.00 | 0.56 | 0.20 | 0.00 | 0.86 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| PDK4 | ENSG00000004799 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.56 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| VGF | ENSG00000128564 | 0.00 | 1.53 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 1.50 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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