Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PSMB8 | ENSG00000204264 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PSMB9 | ENSG00000240065 | 1.11 | 0.76 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| RXRB | ENSG00000204231 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 1.94 | 0.38 | 0.64 | 0.00 | 0.49 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| HSD17B8 | ENSG00000204228 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CDKN1A | ENSG00000124762 | 0.00 | 9.16 | 0.21 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 3.08 | 0.27 | 0.00 | 0.00 | 0.20 | 1.94 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 0.71 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| PPIL1 | ENSG00000137168 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| POLR1C | ENSG00000171453 | 1.11 | 1.02 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DEFB112 | ENSG00000180872 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 1.32 | 2.36 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 1.66 | 1.08 | 0.00 | 0.00 | 0.83 | 0.00 | 1.82 | 0.00 |
| GSTA2 | ENSG00000244067 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.20 | 0.83 | 0.22 | 0.00 | 0.00 |
| GSTA1 | ENSG00000243955 | 0.00 | 1.27 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.00 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| GSTA3 | ENSG00000174156 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| GSTA4 | ENSG00000170899 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.25 |
| ICK | ENSG00000112144 | 1.11 | 1.27 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.90 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| TINAG | ENSG00000137251 | 1.11 | 1.02 | 0.72 | 0.36 | 0.00 | 1.29 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.81 | 0.71 | 1.47 | 0.39 | 1.11 | 2.64 | 2.36 | 0.00 | 1.72 | 0.57 | 0.56 | 0.61 | 0.00 | 0.43 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| COL21A1 | ENSG00000124749 | 1.11 | 1.78 | 0.31 | 1.82 | 0.00 | 0.32 | 13.51 | 2.76 | 0.26 | 0.80 | 0.00 | 0.54 | 0.36 | 0.00 | 0.59 | 0.00 | 4.71 | 3.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.81 | 0.78 | 0.43 | 13.03 | 1.90 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CYB5R4 | ENSG00000065615 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 2.58 | 0.00 | 0.49 | 0.57 | 0.00 | 0.61 | 0.00 | 0.00 | 1.90 | 0.54 | 0.00 | 0.41 | 0.00 | 1.11 | 0.00 | 0.00 |
| RNGTT | ENSG00000111880 | 0.00 | 1.27 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.59 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| KLHL32 | ENSG00000186231 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 1.39 | 1.32 | 2.15 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.86 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PREP | ENSG00000085377 | 0.00 | 0.76 | 0.52 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 1.07 | 1.47 | 0.00 | 0.00 | 0.38 | 1.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| NR2E1 | ENSG00000112333 | 0.00 | 0.00 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.71 | 0.74 | 0.00 | 0.28 | 1.13 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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