Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| HIST1H4C | ENSG00000197061 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| HIST1H4D | ENSG00000277157 | |||||||||||||||||||||||||||||||||
| HIST1H3D | ENSG00000197409 | 1.11 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 1.10 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| HIST1H4E | ENSG00000276966 | |||||||||||||||||||||||||||||||||
| HIST1H3E | ENSG00000274750 | |||||||||||||||||||||||||||||||||
| HIST1H4F | ENSG00000274618 | |||||||||||||||||||||||||||||||||
| HIST1H4H | ENSG00000158406 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 5.41 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| HIST1H4I | ENSG00000276180 | |||||||||||||||||||||||||||||||||
| HIST1H3H | ENSG00000278828 | |||||||||||||||||||||||||||||||||
| HIST1H4J | ENSG00000197238 | 0.00 | 0.25 | 0.41 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| HIST1H3I | ENSG00000275379 | |||||||||||||||||||||||||||||||||
| HIST1H4L | ENSG00000275126 | |||||||||||||||||||||||||||||||||
| HIST1H3J | ENSG00000197153 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| GPX6 | ENSG00000198704 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| OR2H5P | ENSG00000232173 | |||||||||||||||||||||||||||||||||
| TRIM39 | ENSG00000204599 | 2.22 | 1.02 | 0.21 | 1.09 | 2.86 | 0.65 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 1.50 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| HSPA1A | ENSG00000204389 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 1.23 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| HSPA1B | ENSG00000204388 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.82 | 0.00 |
| EHMT2 | ENSG00000204371 | 2.22 | 2.04 | 0.21 | 2.19 | 2.86 | 0.32 | 0.00 | 0.55 | 0.52 | 1.39 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 1.11 | 0.94 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 2.34 | 0.43 | 2.61 | 2.17 | 0.00 | 0.20 | 0.83 | 1.77 | 0.00 | 1.25 |
| STK19 | ENSG00000204344 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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