Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| HMGB2 | ENSG00000164104 | 0.00 | 1.53 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| NEIL3 | ENSG00000109674 | 0.00 | 1.27 | 0.00 | 0.36 | 2.86 | 0.65 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.75 | 1.29 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.54 | 0.69 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| AGA | ENSG00000038002 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 5.41 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 0.71 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| PRIMPOL | ENSG00000164306 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 0.00 | 0.00 | 1.15 | 0.00 | 0.20 | 0.00 | 0.86 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| BRD9 | ENSG00000028310 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ADAMTS16 | ENSG00000145536 | 3.33 | 3.82 | 0.83 | 4.01 | 2.86 | 6.13 | 0.00 | 3.87 | 2.84 | 2.19 | 0.00 | 0.81 | 1.07 | 0.74 | 0.59 | 1.39 | 8.10 | 9.01 | 0.00 | 0.98 | 2.87 | 0.00 | 0.81 | 6.25 | 0.00 | 6.87 | 5.69 | 0.00 | 0.41 | 0.00 | 2.88 | 3.64 | 0.00 |
| ADAMTS12 | ENSG00000151388 | 0.00 | 5.34 | 0.72 | 2.19 | 2.86 | 3.23 | 0.00 | 3.87 | 1.80 | 3.59 | 0.00 | 2.98 | 1.07 | 0.00 | 0.39 | 2.22 | 14.88 | 16.74 | 0.00 | 1.72 | 3.45 | 0.56 | 0.61 | 3.13 | 0.43 | 7.35 | 5.42 | 0.00 | 0.00 | 0.00 | 2.66 | 3.64 | 0.00 |
| PELO | ENSG00000152684 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.00 | 0.27 | 0.00 | 0.41 | 0.00 | 0.67 | 0.00 | 0.00 |
| ESM1 | ENSG00000164283 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.74 | 0.00 | 0.56 | 0.94 | 0.43 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PPWD1 | ENSG00000113593 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.00 | 2.70 | 1.10 | 0.00 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.43 | 1.18 | 0.00 | 0.69 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| SMN1 | ENSG00000172062 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| MCCC2 | ENSG00000131844 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 1.08 | 0.36 | 1.47 | 0.00 | 0.28 | 0.94 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PDE8B | ENSG00000113231 | 2.22 | 0.76 | 0.10 | 0.73 | 0.00 | 1.29 | 0.00 | 1.66 | 0.52 | 1.79 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 2.15 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 1.25 |
| BHMT2 | ENSG00000132840 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.56 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| BHMT | ENSG00000145692 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.54 | 1.42 | 0.00 | 0.00 | 0.00 | 1.32 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| DHFR | ENSG00000228716 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| HAPLN1 | ENSG00000145681 | 1.11 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.60 | 1.54 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 2.07 | 2.58 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 3.32 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| EDIL3 | ENSG00000164176 | 0.00 | 1.78 | 0.00 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 1.08 | 0.71 | 0.00 | 0.00 | 0.56 | 3.77 | 1.50 | 1.23 | 1.23 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 2.61 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| NR2F1 | ENSG00000175745 | 2.22 | 1.02 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.94 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| LECT2 | ENSG00000145826 | 0.00 | 1.02 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
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