Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| MBNL1 | ENSG00000152601 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PLCH1 | ENSG00000114805 | 0.00 | 3.56 | 1.34 | 4.38 | 0.00 | 1.29 | 5.41 | 1.66 | 0.77 | 3.19 | 0.00 | 0.54 | 0.36 | 0.74 | 0.59 | 0.83 | 3.01 | 8.37 | 0.00 | 2.70 | 0.57 | 1.12 | 0.81 | 2.34 | 0.86 | 10.90 | 1.63 | 0.00 | 0.20 | 0.83 | 2.66 | 0.00 | 0.00 |
| PTX3 | ENSG00000163661 | 1.11 | 0.51 | 0.21 | 0.73 | 0.00 | 0.65 | 2.70 | 0.55 | 0.00 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KLHL6 | ENSG00000172578 | 1.11 | 1.53 | 0.21 | 1.09 | 0.00 | 0.65 | 13.51 | 1.66 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 2.07 | 1.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.90 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| KLHL24 | ENSG00000114796 | 1.11 | 1.27 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 1.59 | 0.00 | 0.81 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 1.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 1.08 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| MAP3K13 | ENSG00000073803 | 0.00 | 2.80 | 0.83 | 2.55 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.39 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 1.51 | 1.72 | 1.23 | 0.98 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| TP63 | ENSG00000073282 | 0.00 | 3.31 | 0.00 | 2.55 | 0.00 | 0.97 | 0.00 | 0.55 | 1.55 | 2.39 | 3.08 | 0.54 | 0.36 | 0.00 | 0.59 | 0.83 | 1.32 | 2.15 | 0.00 | 0.74 | 0.00 | 0.56 | 0.41 | 0.78 | 0.43 | 11.14 | 2.17 | 0.69 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| CYTL1 | ENSG00000170891 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR7E85P | ENSG00000250884 | |||||||||||||||||||||||||||||||||
| HS3ST1 | ENSG00000002587 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 1.10 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 1.32 | 0.21 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 2.84 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| FGFBP2 | ENSG00000137441 | 1.11 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| QDPR | ENSG00000151552 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PI4K2B | ENSG00000038210 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| PPAT | ENSG00000128059 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.24 | 1.08 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| SULT1B1 | ENSG00000173597 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.80 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 2.07 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| SULT1E1 | ENSG00000109193 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.69 | 1.29 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.84 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CSN2 | ENSG00000135222 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ODAM | ENSG00000109205 | 1.11 | 1.02 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.98 | 0.00 | 0.56 | 0.20 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SMR3A | ENSG00000109208 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SMR3B | ENSG00000171201 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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