Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GPX1 | ENSG00000233276 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.69 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| RBM5 | ENSG00000003756 | 0.00 | 2.29 | 0.41 | 1.82 | 0.00 | 0.65 | 2.70 | 0.55 | 0.26 | 1.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.75 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 1.90 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| MANF | ENSG00000145050 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| ACY1 | ENSG00000243989 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| DUSP7 | ENSG00000164086 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TNNC1 | ENSG00000114854 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PDE12 | ENSG00000174840 | 0.00 | 1.78 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.00 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.41 | 0.00 | 0.89 | 0.00 | 0.00 |
| KBTBD8 | ENSG00000163376 | 0.00 | 0.51 | 0.31 | 0.00 | 2.86 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.81 | 0.36 | 0.00 | 0.39 | 0.28 | 1.51 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 3.55 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| MITF | ENSG00000187098 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.97 | 2.70 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.28 | 0.75 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 3.13 | 0.00 | 0.71 | 1.08 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| RYBP | ENSG00000163602 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 0.21 | 0.00 | 0.00 | 1.15 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GBE1 | ENSG00000114480 | 0.00 | 0.76 | 0.93 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 2.84 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| DHFRL1 | ENSG00000178700 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.69 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| COL8A1 | ENSG00000144810 | 0.00 | 0.76 | 0.52 | 1.46 | 0.00 | 0.32 | 5.41 | 1.10 | 0.26 | 1.00 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.00 | 0.19 | 2.79 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 5.21 | 1.90 | 0.00 | 0.20 | 0.00 | 2.44 | 0.00 | 0.00 |
| SENP7 | ENSG00000138468 | 0.00 | 2.04 | 0.62 | 1.09 | 0.00 | 0.97 | 0.00 | 1.66 | 1.55 | 0.80 | 0.00 | 0.54 | 0.36 | 0.74 | 0.39 | 0.83 | 1.88 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| MORC1 | ENSG00000114487 | 0.00 | 3.82 | 1.34 | 0.36 | 2.86 | 0.00 | 0.00 | 2.21 | 1.03 | 2.59 | 0.00 | 0.54 | 0.71 | 0.00 | 0.78 | 1.11 | 3.01 | 6.65 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 2.34 | 0.43 | 13.27 | 1.90 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| POGLUT1 | ENSG00000163389 | 0.00 | 1.02 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.59 | 0.00 | 0.19 | 1.72 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.20 | 0.83 | 0.22 | 0.00 | 0.00 |
| NR1I2 | ENSG00000144852 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.83 | 0.19 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| KBTBD12 | ENSG00000187715 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.59 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.56 | 1.50 | 0.00 | 0.25 | 0.57 | 0.56 | 0.00 | 0.00 | 1.29 | 3.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NME9 | ENSG00000181322 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| PCOLCE2 | ENSG00000163710 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.88 | 1.93 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 1.63 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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