Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TAB1 | ENSG00000100324 | 1.11 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.28 | 0.38 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| XPNPEP3 | ENSG00000196236 | 0.00 | 0.51 | 0.62 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 1.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| EP300 | ENSG00000100393 | 1.11 | 13.74 | 1.34 | 10.58 | 0.00 | 2.26 | 2.70 | 4.42 | 0.77 | 7.37 | 0.00 | 2.17 | 2.49 | 2.94 | 0.00 | 2.22 | 1.13 | 3.65 | 1.23 | 1.72 | 1.72 | 0.00 | 0.81 | 2.34 | 0.43 | 3.79 | 1.36 | 0.69 | 0.00 | 0.00 | 6.43 | 1.82 | 1.25 |
| PPARA | ENSG00000186951 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.66 | 0.00 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 1.25 |
| BRD1 | ENSG00000100425 | 1.11 | 1.02 | 0.21 | 1.46 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 1.00 | 1.54 | 0.81 | 0.71 | 0.00 | 0.39 | 0.28 | 1.13 | 0.86 | 0.00 | 1.23 | 0.00 | 0.56 | 0.20 | 1.56 | 0.00 | 3.79 | 1.36 | 0.00 | 0.00 | 0.00 | 4.88 | 0.00 | 0.00 |
| PPARG | ENSG00000132170 | 0.00 | 3.31 | 0.41 | 0.36 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.28 | 0.94 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.27 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| OXNAD1 | ENSG00000154814 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PLCL2 | ENSG00000154822 | 0.00 | 3.05 | 1.24 | 1.46 | 0.00 | 0.65 | 2.70 | 0.00 | 0.52 | 1.79 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 2.07 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 6.87 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| KAT2B | ENSG00000114166 | 0.00 | 1.02 | 0.41 | 0.36 | 0.00 | 0.97 | 2.70 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.51 | 1.29 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.13 | 1.36 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| NR1D2 | ENSG00000174738 | 0.00 | 2.29 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.66 | 1.36 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| THRB | ENSG00000151090 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 1.29 | 2.70 | 0.00 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.39 | 0.28 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.79 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| RARB | ENSG00000077092 | 0.00 | 1.27 | 0.72 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.74 | 0.57 | 0.00 | 0.41 | 0.78 | 1.29 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| TOP2B | ENSG00000077097 | 0.00 | 1.02 | 0.10 | 1.09 | 0.00 | 0.97 | 2.70 | 1.10 | 0.52 | 0.60 | 1.54 | 0.27 | 0.71 | 0.00 | 0.20 | 1.39 | 0.94 | 0.86 | 0.00 | 0.25 | 1.15 | 0.00 | 0.41 | 0.78 | 0.86 | 1.90 | 1.36 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| MLH1 | ENSG00000076242 | 1.11 | 1.78 | 0.31 | 1.09 | 0.00 | 1.61 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.28 | 1.13 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| PLCD1 | ENSG00000187091 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.00 | 0.00 | 0.54 | 1.07 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| CCK | ENSG00000187094 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.00 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 |
| SETD2 | ENSG00000181555 | 2.22 | 5.09 | 1.55 | 4.01 | 2.86 | 2.58 | 0.00 | 1.66 | 2.06 | 1.99 | 1.54 | 13.28 | 6.05 | 1.47 | 1.76 | 3.89 | 6.40 | 3.00 | 9.88 | 1.96 | 0.57 | 1.12 | 1.43 | 3.91 | 0.43 | 4.03 | 2.44 | 0.00 | 0.41 | 0.00 | 4.66 | 0.00 | 1.25 |
| KLHL18 | ENSG00000114648 | 0.00 | 0.76 | 0.21 | 0.73 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 1.47 | 0.20 | 0.28 | 1.32 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PTPN23 | ENSG00000076201 | 2.22 | 0.76 | 0.31 | 0.00 | 0.00 | 0.97 | 0.00 | 1.66 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.74 | 0.59 | 0.83 | 0.75 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 1.56 | 0.00 | 0.95 | 1.08 | 0.69 | 0.00 | 0.00 | 2.44 | 3.64 | 0.00 |
| CDC25A | ENSG00000164045 | 0.00 | 1.27 | 0.10 | 0.73 | 0.00 | 0.97 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.94 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
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