Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| IL1B | ENSG00000125538 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IL37 | ENSG00000125571 | 0.00 | 0.25 | 0.41 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IL36G | ENSG00000136688 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| IL36B | ENSG00000136696 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 4.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IL36RN | ENSG00000136695 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IL1F10 | ENSG00000136697 | 0.00 | 0.76 | 0.10 | 0.00 | 2.86 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| C1QL2 | ENSG00000144119 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| PTPN18 | ENSG00000072135 | 0.00 | 0.00 | 0.21 | 1.09 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.83 | 0.89 | 1.82 | 0.00 |
| TNFAIP6 | ENSG00000123610 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.00 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| NR4A2 | ENSG00000153234 | 2.22 | 0.25 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.83 | 2.07 | 0.86 | 1.23 | 0.74 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 0.95 | 1.36 | 0.00 | 0.20 | 0.83 | 2.22 | 0.00 | 0.00 |
| PSMD14 | ENSG00000115233 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PPIG | ENSG00000138398 | 0.00 | 1.53 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.77 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.39 | 0.56 | 1.69 | 1.50 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 1.42 | 1.08 | 0.00 | 0.20 | 0.00 | 2.66 | 0.00 | 0.00 |
| KLHL23 | ENSG00000213160 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.38 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 3.13 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| METAP1D | ENSG00000172878 | 0.00 | 1.02 | 0.41 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.13 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| pk | ENSG00000091436 | 0.00 | 1.78 | 0.41 | 1.09 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 0.80 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 1.07 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| STAT1 | ENSG00000115415 | 0.00 | 2.54 | 0.10 | 0.73 | 0.00 | 0.65 | 2.70 | 1.10 | 0.52 | 1.39 | 0.00 | 0.27 | 1.07 | 0.00 | 0.00 | 1.11 | 1.32 | 0.86 | 1.23 | 0.25 | 0.57 | 0.00 | 0.20 | 2.34 | 0.43 | 1.66 | 1.36 | 0.69 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| PLCL1 | ENSG00000115896 | 1.11 | 3.05 | 0.62 | 1.09 | 2.86 | 0.97 | 2.70 | 4.42 | 1.29 | 3.19 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 1.11 | 4.71 | 5.58 | 0.00 | 0.74 | 0.00 | 0.56 | 0.41 | 1.56 | 0.43 | 4.27 | 4.61 | 0.69 | 0.41 | 0.00 | 2.66 | 3.64 | 0.00 |
| CTDSP1 | ENSG00000144579 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.75 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| PDE6D | ENSG00000156973 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KLHL30 | ENSG00000168427 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.56 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
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