Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| NRBP1 | ENSG00000115216 | 0.00 | 1.02 | 0.31 | 1.09 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 1.07 | 0.00 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CAPN13 | ENSG00000162949 | 0.00 | 0.51 | 0.31 | 0.36 | 2.86 | 0.00 | 0.00 | 1.66 | 0.52 | 1.00 | 0.00 | 0.00 | 1.78 | 0.74 | 0.20 | 0.00 | 2.07 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.00 | 1.72 | 7.35 | 0.54 | 0.00 | 0.20 | 0.83 | 1.55 | 0.00 | 0.00 |
| PPM1B | ENSG00000138032 | 0.00 | 1.27 | 0.52 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 1.51 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PREPL | ENSG00000138078 | 0.00 | 1.78 | 0.83 | 0.73 | 0.00 | 0.00 | 0.00 | 1.66 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.51 | 1.29 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 1.90 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| EPAS1 | ENSG00000116016 | 0.00 | 1.02 | 0.83 | 1.82 | 0.00 | 0.65 | 0.00 | 2.76 | 1.29 | 1.59 | 0.00 | 0.54 | 1.07 | 0.00 | 0.20 | 0.83 | 1.88 | 1.07 | 0.00 | 0.49 | 0.00 | 4.49 | 0.20 | 0.00 | 0.00 | 1.42 | 0.81 | 0.69 | 0.00 | 0.83 | 2.00 | 1.82 | 0.00 |
| REL | ENSG00000162924 | 0.00 | 1.02 | 0.00 | 2.19 | 0.00 | 0.32 | 2.70 | 1.10 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.56 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SPR | ENSG00000116096 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| DUSP11 | ENSG00000144048 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 1.25 |
| REG1A | ENSG00000115386 | 0.00 | 1.53 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 2.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 2.64 | 4.94 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| USP39 | ENSG00000168883 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.81 | 0.69 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| GNLY | ENSG00000115523 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PLGLB2 | ENSG00000125551 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| DRD5P1 | ENSG00000184303 | |||||||||||||||||||||||||||||||||
| LYG2 | ENSG00000185674 | 1.11 | 1.27 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LYG1 | ENSG00000144214 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TXNDC9 | ENSG00000115514 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SULT1C2 | ENSG00000198203 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.56 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RANBP2 | ENSG00000153201 | 2.22 | 5.34 | 1.65 | 3.28 | 0.00 | 1.29 | 2.70 | 3.87 | 0.77 | 2.19 | 0.00 | 1.90 | 3.20 | 2.94 | 1.18 | 3.06 | 4.90 | 6.01 | 1.23 | 1.96 | 0.57 | 1.12 | 0.41 | 2.34 | 0.86 | 4.74 | 4.07 | 0.69 | 0.00 | 0.00 | 6.43 | 1.82 | 0.00 |
| TTL | ENSG00000114999 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.00 | 0.56 | 0.21 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.00 | 0.81 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| IL1A | ENSG00000115008 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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