Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ADAMTS10 | ENSG00000142303 | 0.00 | 2.29 | 0.21 | 1.09 | 0.00 | 1.29 | 0.00 | 1.10 | 1.03 | 1.79 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 1.11 | 1.13 | 1.72 | 0.00 | 0.74 | 0.57 | 0.56 | 0.41 | 2.34 | 0.00 | 4.98 | 1.90 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 1.25 |
| ANGPTL6 | ENSG00000130812 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.20 | 0.83 | 0.22 | 0.00 | 0.00 |
| KEAP1 | ENSG00000079999 | 2.22 | 1.78 | 0.10 | 0.73 | 5.71 | 0.00 | 0.00 | 1.66 | 0.00 | 3.98 | 0.00 | 0.54 | 0.71 | 0.74 | 0.00 | 5.00 | 17.14 | 10.52 | 0.00 | 0.49 | 0.57 | 0.00 | 0.41 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| PODNL1 | ENSG00000132000 | 0.00 | 0.00 | 0.00 | 1.09 | 0.00 | 0.32 | 2.70 | 0.55 | 1.03 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 0.00 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SAMD1 | ENSG00000141858 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.81 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| CASP14 | ENSG00000105141 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.54 | 0.00 | 0.74 | 0.20 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.81 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 1.25 |
| NR2F6 | ENSG00000160113 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| JAK3 | ENSG00000105639 | 2.22 | 2.29 | 0.72 | 1.09 | 0.00 | 0.65 | 2.70 | 1.66 | 0.77 | 0.80 | 0.00 | 0.54 | 0.36 | 0.74 | 0.39 | 1.94 | 1.51 | 1.93 | 0.00 | 2.21 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.90 | 1.08 | 0.00 | 0.00 | 0.00 | 2.88 | 1.82 | 0.00 |
| PIK3R2 | ENSG00000105647 | 1.11 | 1.02 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 1.03 | 0.60 | 0.00 | 1.08 | 0.36 | 0.00 | 0.00 | 0.56 | 0.56 | 2.36 | 0.00 | 0.49 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| CILP2 | ENSG00000160161 | 1.11 | 2.29 | 0.21 | 0.73 | 0.00 | 2.26 | 8.11 | 1.66 | 1.80 | 1.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.39 | 1.67 | 2.64 | 2.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 1.29 | 6.40 | 2.44 | 0.69 | 0.20 | 0.00 | 1.55 | 1.82 | 0.00 |
| SBSN | ENSG00000189001 | 1.11 | 0.00 | 0.31 | 1.09 | 0.00 | 0.32 | 0.00 | 0.00 | 1.03 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 2.64 | 2.58 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.83 | 0.89 | 0.00 | 0.00 |
| LGALS7B | ENSG00000178934 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SYCN | ENSG00000179751 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ITPKC | ENSG00000086544 | 0.00 | 1.02 | 0.72 | 1.82 | 0.00 | 0.97 | 2.70 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| EGLN2 | ENSG00000269858 | 0.00 | 1.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.56 | 0.56 | 0.21 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RELB | ENSG00000104856 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| SULT2A1 | ENSG00000105398 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.20 | 0.00 | 0.22 | 1.82 | 0.00 |
| LIG1 | ENSG00000105486 | 0.00 | 0.51 | 0.21 | 2.19 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 1.29 | 0.00 | 0.25 | 0.57 | 0.56 | 0.20 | 0.00 | 0.00 | 2.37 | 1.36 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| CARD8 | ENSG00000105483 | 0.00 | 0.51 | 0.52 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.32 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.08 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SULT2B1 | ENSG00000088002 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.56 | 0.00 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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