Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| IGFBP4 | ENSG00000141753 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TNS4 | ENSG00000131746 | 1.11 | 1.27 | 0.52 | 0.36 | 0.00 | 0.97 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 0.00 | 0.36 | 0.74 | 0.20 | 0.28 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.55 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| KRT19 | ENSG00000171345 | 0.00 | 1.53 | 0.52 | 0.73 | 0.00 | 0.00 | 2.70 | 0.55 | 1.03 | 0.20 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.56 | 0.56 | 0.43 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 0.81 | 0.69 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| GAST | ENSG00000184502 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| CNP | ENSG00000173786 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| STAT5B | ENSG00000173757 | 0.00 | 0.76 | 0.62 | 1.46 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 1.00 | 0.00 | 0.27 | 0.71 | 0.74 | 0.20 | 0.28 | 1.13 | 0.43 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.08 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| STAT5A | ENSG00000126561 | 0.00 | 0.25 | 0.62 | 0.36 | 2.86 | 0.97 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.18 | 0.81 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| STAT3 | ENSG00000168610 | 0.00 | 0.76 | 0.72 | 1.46 | 0.00 | 0.65 | 16.22 | 0.55 | 0.26 | 1.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 1.11 | 1.51 | 1.29 | 0.00 | 0.98 | 0.00 | 0.56 | 1.02 | 0.00 | 0.00 | 1.42 | 0.81 | 0.69 | 0.00 | 0.00 | 2.44 | 3.64 | 0.00 |
| MLX | ENSG00000108788 | 1.11 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.81 | 0.69 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| HDAC5 | ENSG00000108840 | 0.00 | 1.02 | 0.52 | 1.46 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.40 | 1.54 | 0.00 | 1.07 | 0.00 | 0.20 | 0.56 | 0.38 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.41 | 0.00 | 0.43 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 2.50 |
| NPEPPS | ENSG00000141279 | 1.11 | 2.04 | 0.41 | 0.36 | 0.00 | 0.00 | 2.70 | 1.10 | 0.26 | 0.80 | 0.00 | 0.81 | 0.71 | 0.00 | 0.20 | 0.83 | 0.94 | 1.29 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.81 | 0.00 | 0.20 | 0.00 | 1.33 | 1.82 | 0.00 |
| PDK2 | ENSG00000005882 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 1.54 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| H3F3B | ENSG00000132475 | 0.00 | 1.53 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
| PDE6G | ENSG00000185527 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TXNDC2 | ENSG00000168454 | 0.00 | 1.02 | 0.21 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.74 | 0.39 | 0.28 | 0.75 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 3.08 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| TXNL1 | ENSG00000091164 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| SERPINB12 | ENSG00000166634 | 1.11 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 1.54 | 0.00 | 0.00 | 0.00 | 0.59 | 0.28 | 1.51 | 1.07 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| NFATC1 | ENSG00000131196 | 0.00 | 2.54 | 0.31 | 0.36 | 0.00 | 1.29 | 0.00 | 1.66 | 0.77 | 1.20 | 1.54 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 1.32 | 2.58 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 2.61 | 0.81 | 0.00 | 0.20 | 0.00 | 2.22 | 1.82 | 0.00 |
| PSPN | ENSG00000125650 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.44 | 0.00 | 0.00 |
| ELAVL1 | ENSG00000066044 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 5.41 | 1.10 | 0.52 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
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