Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| EIF4A1 | ENSG00000161960 | 0.00 | 0.76 | 0.00 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.98 | 0.00 | 0.38 | 0.00 | 1.23 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TP53 | ENSG00000141510 | 16.67 | 48.09 | 33.99 | 6.93 | 11.43 | 64.84 | 13.51 | 86.74 | 30.41 | 70.12 | 30.77 | 2.98 | 2.14 | 6.62 | 48.43 | 29.72 | 48.78 | 83.69 | 17.28 | 90.69 | 62.07 | 0.56 | 11.61 | 82.03 | 34.91 | 11.14 | 51.49 | 0.69 | 0.61 | 2.48 | 39.47 | 92.73 | 0.00 |
| MAPK7 | ENSG00000166484 | 0.00 | 0.51 | 0.00 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.83 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| MTRNR2L1 | ENSG00000256618 | |||||||||||||||||||||||||||||||||
| LGALS9 | ENSG00000168961 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 1.69 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 1.25 |
| NOS2 | ENSG00000007171 | 1.11 | 1.78 | 0.52 | 1.09 | 0.00 | 1.29 | 0.00 | 0.55 | 0.77 | 1.20 | 0.00 | 0.54 | 0.71 | 0.74 | 0.39 | 1.39 | 3.01 | 3.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.81 | 0.00 | 0.86 | 2.84 | 1.63 | 0.00 | 0.00 | 0.83 | 2.00 | 1.82 | 0.00 |
| SDF2 | ENSG00000132581 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| SSH2 | ENSG00000141298 | 0.00 | 2.54 | 0.52 | 1.46 | 0.00 | 0.32 | 0.00 | 2.21 | 0.77 | 1.39 | 0.00 | 1.08 | 2.14 | 0.00 | 0.00 | 0.56 | 0.75 | 3.22 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 1.66 | 2.98 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| BLMH | ENSG00000108578 | 1.11 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.47 | 0.54 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| CCL8 | ENSG00000108700 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CCL13 | ENSG00000181374 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| CCL18 | ENSG00000275385 | |||||||||||||||||||||||||||||||||
| CCL3L3 | ENSG00000276085 | |||||||||||||||||||||||||||||||||
| PSMB3 | ENSG00000277791 | |||||||||||||||||||||||||||||||||
| CDK12 | ENSG00000167258 | 0.00 | 5.60 | 0.93 | 5.84 | 0.00 | 1.29 | 2.70 | 1.66 | 0.77 | 1.20 | 0.00 | 1.90 | 0.71 | 0.00 | 0.78 | 0.56 | 2.64 | 2.58 | 0.00 | 4.66 | 0.00 | 0.00 | 1.83 | 0.78 | 0.43 | 1.90 | 2.44 | 0.69 | 0.20 | 0.00 | 3.10 | 0.00 | 0.00 |
| PNMT | ENSG00000141744 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CSF3 | ENSG00000108342 | 0.00 | 0.25 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| THRA | ENSG00000126351 | 1.11 | 0.51 | 0.31 | 0.36 | 0.00 | 0.65 | 2.70 | 1.10 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 0.74 | 0.00 | 0.00 | 0.75 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 1.56 | 0.43 | 1.18 | 0.81 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| NR1D1 | ENSG00000126368 | 0.00 | 0.76 | 0.41 | 1.09 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 1.47 | 0.00 | 0.28 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TOP2A | ENSG00000131747 | 2.22 | 2.04 | 0.41 | 1.46 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 1.39 | 1.88 | 1.72 | 1.23 | 4.66 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 2.84 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
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