Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| ERCC5 | ENSG00000134899 | 1.11 | 0.25 | 0.10 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.75 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| OR11H13P | ENSG00000196143 | |||||||||||||||||||||||||||||||||
| PARP2 | ENSG00000129484 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 1.29 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| APEX1 | ENSG00000100823 | 1.11 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PRMT5 | ENSG00000100462 | 0.00 | 1.02 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.59 | 0.00 | 0.94 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PSMB11 | ENSG00000222028 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.83 | 0.94 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| MYH6 | ENSG00000197616 | 1.11 | 2.29 | 1.24 | 2.55 | 0.00 | 2.58 | 2.70 | 2.21 | 2.32 | 3.59 | 0.00 | 1.08 | 1.42 | 0.74 | 0.78 | 2.50 | 7.16 | 6.01 | 1.23 | 0.74 | 0.57 | 0.00 | 1.22 | 1.56 | 0.43 | 6.16 | 2.17 | 0.69 | 0.41 | 0.00 | 3.55 | 0.00 | 1.25 |
| MYH7 | ENSG00000092054 | 0.00 | 4.83 | 1.86 | 2.92 | 0.00 | 0.65 | 0.00 | 3.87 | 0.77 | 2.99 | 0.00 | 1.36 | 1.78 | 0.00 | 0.78 | 3.06 | 7.72 | 8.80 | 1.23 | 1.47 | 1.72 | 0.00 | 0.81 | 0.78 | 2.59 | 10.66 | 3.25 | 0.69 | 0.20 | 0.00 | 4.88 | 3.64 | 0.00 |
| DHRS1 | ENSG00000157379 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| EGLN3 | ENSG00000129521 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FKBP3 | ENSG00000100442 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| PSMA3 | ENSG00000100567 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ESR2 | ENSG00000140009 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.65 | 2.70 | 0.55 | 0.00 | 0.20 | 1.54 | 0.54 | 0.71 | 0.00 | 0.39 | 0.56 | 0.56 | 1.72 | 1.23 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 1.29 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GPX2 | ENSG00000176153 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ATP6V1D | ENSG00000100554 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PAPLN | ENSG00000100767 | 0.00 | 0.76 | 0.31 | 0.73 | 0.00 | 1.61 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.28 | 0.75 | 1.72 | 1.23 | 0.98 | 0.57 | 0.00 | 0.41 | 1.56 | 0.00 | 4.50 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| MLH3 | ENSG00000119684 | 0.00 | 0.51 | 0.52 | 1.09 | 0.00 | 1.61 | 0.00 | 0.00 | 1.03 | 1.00 | 0.00 | 1.63 | 1.07 | 0.00 | 0.20 | 1.94 | 1.13 | 2.15 | 0.00 | 0.25 | 0.57 | 0.56 | 0.61 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| FOS | ENSG00000170345 | 0.00 | 1.02 | 0.10 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GSTZ1 | ENSG00000100577 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PSMC1 | ENSG00000100764 | 1.11 | 0.25 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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