Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| BBOX1 | ENSG00000129151 | 0.00 | 1.02 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 1.32 | 0.21 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.25 |
| HSP90AA2P | ENSG00000224411 | |||||||||||||||||||||||||||||||||
| CAT | ENSG00000121691 | 0.00 | 2.04 | 0.21 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| NR1H3 | ENSG00000025434 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.83 | 0.56 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| AGBL2 | ENSG00000165923 | 1.11 | 0.51 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 1.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.28 | 1.32 | 1.93 | 1.23 | 0.98 | 0.57 | 0.56 | 0.00 | 0.78 | 0.43 | 2.37 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CNTF | ENSG00000242689 | 0.00 | 1.02 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PGA3 | ENSG00000229859 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FEN1 | ENSG00000168496 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SCGB1D1 | ENSG00000168515 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SCGB2A1 | ENSG00000124939 | 1.11 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SCGB1D2 | ENSG00000124935 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| VEGFB | ENSG00000173511 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| BAD | ENSG00000002330 | 0.00 | 0.25 | 0.00 | 0.36 | 2.86 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| ESRRA | ENSG00000173153 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| RELA | ENSG00000173039 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.86 | 1.42 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CCS | ENSG00000173992 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| KDM2A | ENSG00000173120 | 0.00 | 1.27 | 0.83 | 2.55 | 0.00 | 0.97 | 0.00 | 0.55 | 0.00 | 0.60 | 1.54 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 0.94 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 1.08 | 2.08 | 0.81 | 0.00 | 1.11 | 0.00 | 0.00 |
| SUV420H1 | ENSG00000110066 | 0.00 | 3.31 | 0.62 | 0.36 | 0.00 | 0.97 | 0.00 | 2.76 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 1.39 | 1.32 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 1.90 | 1.08 | 0.69 | 0.20 | 0.00 | 0.89 | 1.82 | 0.00 |
| OR7E87P | ENSG00000184055 | |||||||||||||||||||||||||||||||||
| CHRDL2 | ENSG00000054938 | 1.11 | 0.76 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.20 | 1.54 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.64 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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