Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TULP3 | ENSG00000078246 | 0.00 | 2.04 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.56 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 0.54 | 0.69 | 0.00 | 0.83 | 1.77 | 0.00 | 0.00 |
| NCEH1 | ENSG00000144959 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.38 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| BMP8A | ENSG00000183682 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ST3GAL1 | ENSG00000008513 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 1.54 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 2.34 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SPINT2 | ENSG00000167642 | 1.11 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.27 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KCNK6 | ENSG00000099337 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.56 | 1.13 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| CACNA1C | ENSG00000151067 | 1.11 | 2.80 | 1.76 | 1.82 | 0.00 | 2.26 | 2.70 | 2.76 | 1.29 | 3.59 | 1.54 | 1.63 | 1.07 | 1.47 | 0.00 | 1.94 | 7.72 | 6.87 | 0.00 | 3.68 | 1.72 | 0.56 | 0.41 | 3.13 | 1.72 | 9.72 | 4.61 | 1.39 | 0.20 | 0.00 | 3.77 | 0.00 | 1.25 |
| MFSD11 | ENSG00000092931 | 0.00 | 1.78 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 1.39 | 0.19 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| MFSD2A | ENSG00000168389 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.75 | 0.43 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SLC47A1 | ENSG00000142494 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 0.65 | 2.70 | 1.10 | 0.00 | 0.80 | 0.00 | 0.81 | 1.42 | 0.74 | 0.20 | 0.83 | 0.38 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.20 | 0.83 | 0.67 | 0.00 | 0.00 |
| F10 | ENSG00000126218 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 1.61 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.83 | 0.94 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.90 | 1.08 | 0.00 | 0.20 | 0.00 | 0.44 | 1.82 | 0.00 |
| SEMA4B | ENSG00000185033 | 0.00 | 1.53 | 0.31 | 2.55 | 0.00 | 0.32 | 2.70 | 1.66 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 0.38 | 0.43 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 3.13 | 0.00 | 1.18 | 0.81 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| ADGRB1 | ENSG00000181790 | 0.00 | 1.53 | 0.72 | 2.55 | 0.00 | 1.61 | 0.00 | 2.76 | 0.52 | 1.39 | 1.54 | 0.27 | 0.71 | 0.00 | 0.59 | 1.39 | 2.82 | 3.65 | 1.23 | 0.98 | 1.15 | 0.00 | 1.02 | 4.69 | 1.72 | 2.61 | 2.98 | 0.00 | 0.20 | 0.83 | 2.00 | 0.00 | 0.00 |
| CD274 | ENSG00000120217 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SRD5A3 | ENSG00000128039 | 0.00 | 0.76 | 0.00 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC45A4 | ENSG00000022567 | 0.00 | 1.02 | 0.31 | 0.73 | 0.00 | 0.32 | 0.00 | 1.66 | 0.77 | 0.40 | 1.54 | 0.54 | 0.36 | 0.00 | 0.39 | 1.11 | 0.75 | 1.72 | 1.23 | 1.23 | 1.72 | 0.00 | 0.20 | 0.00 | 0.86 | 3.08 | 1.36 | 0.00 | 0.00 | 0.83 | 3.33 | 0.00 | 0.00 |
| SLC39A4 | ENSG00000147804 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 0.38 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| FURIN | ENSG00000140564 | 0.00 | 1.78 | 0.31 | 0.73 | 0.00 | 0.97 | 0.00 | 1.66 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.75 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| CD72 | ENSG00000137101 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.59 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PDCD1LG2 | ENSG00000197646 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
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