Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| S100A7 | ENSG00000143556 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| RPS27 | ENSG00000177954 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PKLR | ENSG00000143627 | 0.00 | 1.78 | 0.52 | 1.09 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.56 | 1.51 | 1.72 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 1.08 | 0.00 | 0.20 | 0.83 | 0.89 | 0.00 | 0.00 |
| ASH1L | ENSG00000116539 | 1.11 | 6.36 | 2.27 | 2.92 | 0.00 | 1.94 | 0.00 | 1.10 | 0.77 | 2.19 | 0.00 | 0.81 | 1.42 | 0.00 | 0.20 | 1.67 | 4.71 | 4.72 | 1.23 | 0.98 | 0.57 | 0.56 | 1.22 | 3.91 | 0.43 | 5.92 | 3.79 | 0.00 | 0.41 | 0.00 | 4.88 | 0.00 | 0.00 |
| APOA1BP | ENSG00000163382 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.54 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| HAPLN2 | ENSG00000132702 | 0.00 | 1.02 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| HDGF | ENSG00000143321 | 0.00 | 0.25 | 0.00 | 0.36 | 2.86 | 0.00 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.00 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CD5L | ENSG00000073754 | 0.00 | 1.02 | 0.72 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 1.00 | 3.08 | 0.27 | 0.00 | 0.74 | 0.00 | 1.39 | 2.82 | 3.65 | 0.00 | 0.25 | 0.57 | 0.56 | 1.02 | 1.56 | 0.00 | 3.08 | 2.17 | 0.00 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| COPA | ENSG00000122218 | 0.00 | 2.29 | 0.93 | 0.00 | 0.00 | 1.29 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 1.08 | 0.36 | 0.00 | 0.00 | 1.94 | 1.69 | 2.79 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.61 | 1.08 | 0.69 | 0.00 | 0.00 | 3.77 | 0.00 | 0.00 |
| NR1I3 | ENSG00000143257 | 0.00 | 0.76 | 0.31 | 0.73 | 2.86 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 0.95 | 0.54 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| RGS4 | ENSG00000117152 | 0.00 | 0.25 | 0.52 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 1.03 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.56 | 1.32 | 1.07 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RXRG | ENSG00000143171 | 0.00 | 1.78 | 0.21 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.56 | 2.82 | 3.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 1.25 |
| DPT | ENSG00000143196 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.00 | 0.38 | 0.21 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RNASEL | ENSG00000135828 | 0.00 | 2.29 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 0.56 | 0.75 | 1.29 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| IVNS1ABP | ENSG00000116679 | 0.00 | 2.04 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 0.75 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| F13B | ENSG00000143278 | 0.00 | 1.78 | 0.62 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.00 | 2.39 | 1.54 | 0.54 | 0.00 | 0.74 | 0.59 | 0.28 | 3.39 | 6.44 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 2.34 | 0.43 | 6.16 | 1.90 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| TNNT2 | ENSG00000118194 | 0.00 | 0.00 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.27 | 0.00 | 1.47 | 0.00 | 0.28 | 0.94 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| LAD1 | ENSG00000159166 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.81 | 0.00 | 0.00 | 0.20 | 0.56 | 1.32 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 4.03 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KLHL12 | ENSG00000117153 | 0.00 | 1.53 | 0.41 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.00 | 0.00 | 1.47 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| OPTC | ENSG00000188770 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.77 | 0.20 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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