Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
| Showing page 257 |
first page | previous page | next page | last page |
| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| RSPO1 | ENSG00000169218 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.13 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PPIE | ENSG00000084072 | 0.00 | 0.76 | 0.10 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| BMP8B | ENSG00000116985 | 1.11 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| EDN2 | ENSG00000127129 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PPIH | ENSG00000171960 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| KDM4A | ENSG00000066135 | 0.00 | 1.78 | 0.72 | 0.73 | 0.00 | 1.29 | 0.00 | 1.66 | 1.03 | 0.80 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.28 | 1.13 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| TESK2 | ENSG00000070759 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 1.61 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 0.28 | 0.75 | 0.86 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| PIK3R3 | ENSG00000117461 | 0.00 | 1.27 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.56 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| AGBL4 | ENSG00000186094 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 1.94 | 2.70 | 1.10 | 0.00 | 0.00 | 1.54 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.00 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| GPX7 | ENSG00000116157 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CPT2 | ENSG00000157184 | 0.00 | 1.02 | 0.62 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.20 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| JUN | ENSG00000177606 | 0.00 | 0.76 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.20 | 0.00 | 0.22 | 0.00 | 0.00 |
| USP1 | ENSG00000162607 | 0.00 | 1.02 | 0.72 | 1.82 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 1.13 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| ATG4C | ENSG00000125703 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.65 | 5.41 | 0.00 | 0.00 | 0.20 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 0.28 | 0.38 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| JAK1 | ENSG00000162434 | 1.11 | 1.53 | 0.72 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.77 | 1.59 | 0.00 | 0.81 | 1.07 | 0.00 | 0.00 | 2.78 | 1.32 | 1.29 | 0.00 | 0.00 | 0.57 | 0.00 | 0.61 | 0.78 | 0.43 | 1.42 | 0.54 | 0.00 | 0.20 | 0.00 | 9.53 | 0.00 | 1.25 |
| ZRANB2 | ENSG00000132485 | 1.11 | 0.76 | 0.21 | 2.55 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 1.20 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.28 | 0.94 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TNNI3K | ENSG00000116783 | 1.11 | 1.02 | 0.00 | 0.36 | 2.86 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.83 | 1.32 | 2.15 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 3.32 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| AMY2B | ENSG00000240038 | 0.00 | 1.27 | 0.10 | 0.73 | 0.00 | 0.65 | 2.70 | 3.31 | 1.29 | 1.59 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 0.28 | 2.07 | 2.79 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 1.29 | 2.37 | 3.79 | 0.00 | 0.00 | 0.00 | 2.44 | 1.82 | 0.00 |
| AMY2A | ENSG00000243480 | 0.00 | 1.78 | 0.31 | 0.36 | 0.00 | 1.61 | 0.00 | 0.55 | 1.29 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 2.15 | 0.00 | 0.00 | 1.15 | 0.00 | 0.00 | 4.69 | 0.00 | 1.90 | 0.81 | 0.00 | 0.20 | 0.00 | 1.11 | 1.82 | 0.00 |
| AMY1A | ENSG00000237763 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
|
Showing page 257 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.