Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| MAP3K15 | ENSG00000180815 | 1.11 | 1.02 | 0.62 | 3.65 | 0.00 | 0.97 | 0.00 | 0.55 | 1.03 | 0.80 | 0.00 | 1.36 | 0.36 | 0.00 | 0.59 | 1.67 | 1.32 | 2.79 | 0.00 | 1.47 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 4.50 | 1.90 | 0.00 | 0.20 | 0.00 | 2.88 | 1.82 | 0.00 |
| KLHL15 | ENSG00000174010 | 1.11 | 1.27 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.20 | 0.56 | 0.75 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| POLA1 | ENSG00000101868 | 0.00 | 1.02 | 0.62 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.80 | 0.00 | 0.54 | 0.71 | 0.00 | 0.39 | 0.56 | 3.20 | 2.15 | 0.00 | 0.74 | 0.57 | 0.00 | 0.20 | 3.13 | 0.00 | 0.95 | 0.54 | 1.39 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| CFP | ENSG00000126759 | 0.00 | 0.25 | 0.62 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 1.03 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.83 | 0.94 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 1.25 |
| OTUD5 | ENSG00000068308 | 0.00 | 0.51 | 0.10 | 1.09 | 2.86 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.41 | 0.00 | 1.11 | 0.00 | 0.00 |
| CCNB3 | ENSG00000147082 | 1.11 | 1.53 | 1.24 | 2.55 | 5.71 | 0.65 | 0.00 | 1.10 | 1.03 | 1.99 | 0.00 | 0.54 | 0.00 | 0.00 | 0.39 | 1.11 | 4.33 | 2.79 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 2.34 | 0.86 | 6.40 | 2.71 | 0.69 | 0.00 | 0.00 | 2.44 | 0.00 | 0.00 |
| KDM5C | ENSG00000126012 | 0.00 | 0.51 | 0.52 | 1.09 | 0.00 | 1.29 | 0.00 | 0.55 | 1.29 | 1.59 | 1.54 | 5.15 | 0.71 | 0.00 | 0.20 | 0.83 | 3.20 | 1.93 | 1.23 | 1.72 | 0.00 | 0.56 | 0.00 | 0.78 | 1.29 | 1.66 | 1.90 | 0.00 | 0.00 | 0.00 | 3.33 | 0.00 | 0.00 |
| WNK3 | ENSG00000196632 | 0.00 | 2.54 | 1.55 | 3.65 | 0.00 | 2.58 | 0.00 | 0.55 | 1.55 | 2.99 | 1.54 | 1.36 | 0.36 | 0.74 | 0.78 | 0.83 | 4.14 | 3.00 | 0.00 | 1.96 | 0.00 | 0.00 | 0.61 | 3.13 | 1.72 | 4.50 | 2.17 | 0.69 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| FGF16 | ENSG00000196468 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.56 | 0.41 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| COL4A5 | ENSG00000188153 | 1.11 | 1.27 | 1.24 | 1.82 | 0.00 | 3.55 | 2.70 | 1.66 | 0.52 | 2.19 | 0.00 | 2.44 | 0.00 | 0.00 | 1.18 | 2.78 | 6.03 | 2.36 | 1.23 | 2.45 | 1.15 | 0.00 | 0.41 | 3.13 | 1.29 | 13.98 | 1.63 | 0.69 | 0.20 | 0.00 | 2.00 | 0.00 | 0.00 |
| CHRDL1 | ENSG00000101938 | 0.00 | 0.76 | 0.31 | 0.36 | 0.00 | 1.94 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.00 | 2.26 | 2.15 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 2.13 | 0.81 | 0.69 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| CAPN6 | ENSG00000077274 | 2.22 | 0.51 | 0.52 | 1.46 | 0.00 | 1.29 | 0.00 | 1.66 | 0.77 | 1.59 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 3.39 | 3.22 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 3.32 | 1.36 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| HPRT1 | ENSG00000165704 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| DUSP9 | ENSG00000130829 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.13 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.63 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ISG15 | ENSG00000187608 | 0.00 | 0.00 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| AURKAIP1 | ENSG00000175756 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| VWA1 | ENSG00000179403 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CDK11B | ENSG00000248333 | 0.00 | 0.76 | 0.72 | 1.09 | 0.00 | 0.32 | 2.70 | 1.66 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.43 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| CDK11A | ENSG00000008128 | 0.00 | 1.53 | 0.52 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.27 | 0.00 | 0.20 | 0.00 | 0.67 | 3.64 | 0.00 |
| TP73 | ENSG00000078900 | 0.00 | 1.53 | 0.21 | 3.28 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.75 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 1.08 | 0.69 | 0.41 | 0.83 | 3.33 | 0.00 | 0.00 |
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