Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| IFNA16 | ENSG00000147885 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 1.69 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.90 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 1.82 | 0.00 |
| IFNA5 | ENSG00000147873 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| IFNA2 | ENSG00000188379 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| IFNA8 | ENSG00000120242 | 1.11 | 0.25 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| IFNA1 | ENSG00000197919 | 0.00 | 0.25 | 0.10 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SPINK4 | ENSG00000122711 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PRSS3 | ENSG00000010438 | 1.11 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.27 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CCL21 | ENSG00000137077 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CDK20 | ENSG00000156345 | 0.00 | 0.76 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 2.34 | 0.43 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ECM2 | ENSG00000106823 | 0.00 | 1.78 | 0.52 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HSDL2 | ENSG00000119471 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CRAT | ENSG00000095321 | 0.00 | 2.04 | 0.31 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.52 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.00 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| ABL1 | ENSG00000097007 | 0.00 | 2.04 | 0.62 | 1.82 | 0.00 | 0.97 | 0.00 | 1.10 | 0.52 | 0.80 | 1.54 | 0.54 | 0.71 | 0.00 | 0.00 | 0.28 | 1.13 | 1.07 | 0.00 | 1.47 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 3.55 | 0.81 | 0.00 | 0.00 | 0.00 | 3.10 | 0.00 | 0.00 |
| OBP2B | ENSG00000171102 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| BRD3 | ENSG00000169925 | 2.22 | 0.00 | 0.21 | 0.00 | 0.00 | 0.97 | 2.70 | 0.55 | 0.52 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 0.28 | 0.56 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.86 | 1.42 | 1.08 | 0.00 | 0.20 | 0.00 | 2.66 | 1.82 | 0.00 |
| LCN1 | ENSG00000160349 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.81 | 0.36 | 0.00 | 0.20 | 0.00 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OBP2A | ENSG00000122136 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.20 | 0.00 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| LCN6 | ENSG00000267206 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| ATXN3L | ENSG00000123594 | 1.11 | 0.25 | 0.41 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 1.51 | 1.50 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CDKL5 | ENSG00000008086 | 3.33 | 0.51 | 0.62 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 1.79 | 0.00 | 0.54 | 0.36 | 0.74 | 0.20 | 1.11 | 1.13 | 3.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.86 | 3.08 | 0.27 | 0.00 | 0.20 | 0.83 | 2.88 | 1.82 | 0.00 |
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