Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| LARS | ENSG00000133706 | 0.00 | 2.04 | 0.41 | 0.36 | 0.00 | 1.61 | 0.00 | 1.66 | 0.52 | 0.60 | 0.00 | 0.27 | 1.42 | 0.74 | 0.00 | 0.28 | 1.88 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.66 | 0.27 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| SPINK1 | ENSG00000164266 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SCGB3A2 | ENSG00000164265 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SPINK5 | ENSG00000133710 | 1.11 | 2.04 | 0.83 | 0.73 | 0.00 | 1.29 | 2.70 | 0.55 | 0.00 | 0.40 | 0.00 | 0.81 | 1.42 | 0.00 | 0.39 | 1.39 | 1.13 | 1.07 | 1.23 | 0.49 | 0.57 | 0.56 | 0.20 | 0.78 | 0.43 | 6.40 | 1.08 | 0.00 | 0.20 | 0.00 | 2.22 | 0.00 | 0.00 |
| SPINK7 | ENSG00000145879 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RARS | ENSG00000113643 | 0.00 | 1.02 | 0.52 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.54 | 0.71 | 0.74 | 0.20 | 0.28 | 0.94 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 1.29 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| DUSP1 | ENSG00000120129 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 1.47 | 0.20 | 0.28 | 0.00 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SCGB3A1 | ENSG00000161055 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| NQO2 | ENSG00000124588 | 1.11 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| PRPF4B | ENSG00000112739 | 1.11 | 1.78 | 0.93 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 0.54 | 1.42 | 0.00 | 0.20 | 0.56 | 1.69 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 1.42 | 0.54 | 0.00 | 0.20 | 0.00 | 2.88 | 1.82 | 0.00 |
| MAK | ENSG00000111837 | 0.00 | 1.02 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.19 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.78 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| GMPR | ENSG00000137198 | 0.00 | 0.25 | 0.10 | 0.36 | 2.86 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.75 | 0.21 | 0.00 | 0.00 | 0.57 | 0.56 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| KDM1B | ENSG00000165097 | 0.00 | 1.27 | 0.10 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 1.03 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.28 | 0.94 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 1.82 | 0.00 |
| GPX5 | ENSG00000224586 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 1.32 | 0.86 | 0.00 | 0.00 | 1.15 | 0.00 | 0.00 | 1.56 | 0.86 | 3.79 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| C6orf15 | ENSG00000204542 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 1.11 | 0.38 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| BRD2 | ENSG00000204256 | 0.00 | 3.56 | 0.21 | 1.09 | 2.86 | 0.65 | 2.70 | 1.10 | 1.03 | 0.20 | 0.00 | 0.54 | 1.42 | 0.00 | 0.59 | 0.28 | 0.75 | 0.64 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.78 | 0.86 | 1.42 | 0.81 | 0.00 | 0.00 | 0.83 | 1.55 | 0.00 | 0.00 |
| PPARD | ENSG00000112033 | 0.00 | 1.53 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FKBP5 | ENSG00000096060 | 0.00 | 1.78 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.56 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 2.61 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CLPS | ENSG00000137392 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MAPK13 | ENSG00000156711 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 1.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 0.19 | 0.43 | 1.23 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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