Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SFRP2 | ENSG00000145423 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| GUCY1B3 | ENSG00000061918 | 0.00 | 1.53 | 0.31 | 1.09 | 0.00 | 1.29 | 2.70 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.56 | 0.75 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CTSO | ENSG00000256043 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.47 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| FSTL5 | ENSG00000168843 | 3.33 | 2.04 | 0.83 | 1.09 | 0.00 | 3.55 | 0.00 | 3.87 | 1.03 | 4.18 | 1.54 | 0.27 | 0.36 | 0.00 | 1.37 | 1.94 | 6.40 | 6.22 | 0.00 | 0.74 | 1.15 | 0.00 | 0.41 | 3.13 | 0.43 | 8.77 | 2.71 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| CBR4 | ENSG00000145439 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 1.54 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| HPGD | ENSG00000164120 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| MTRR | ENSG00000124275 | 0.00 | 0.76 | 0.31 | 1.09 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 1.78 | 0.00 | 0.39 | 0.28 | 1.51 | 2.79 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TARS | ENSG00000113407 | 0.00 | 2.04 | 0.52 | 0.73 | 0.00 | 0.32 | 0.00 | 2.21 | 0.26 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 1.51 | 1.07 | 0.00 | 1.23 | 0.57 | 0.00 | 0.41 | 0.00 | 0.43 | 1.18 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| AGXT2 | ENSG00000113492 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.71 | 0.74 | 0.20 | 0.00 | 1.51 | 1.50 | 0.00 | 1.23 | 0.00 | 0.56 | 0.41 | 0.78 | 0.00 | 5.69 | 1.36 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 0.00 |
| EGFLAM | ENSG00000164318 | 2.22 | 2.80 | 0.93 | 1.09 | 0.00 | 0.32 | 0.00 | 1.66 | 1.29 | 2.59 | 0.00 | 0.81 | 0.36 | 1.47 | 0.59 | 2.22 | 4.14 | 4.51 | 0.00 | 2.45 | 0.57 | 0.00 | 0.41 | 1.56 | 0.43 | 7.82 | 2.44 | 0.00 | 0.20 | 0.83 | 2.44 | 1.82 | 0.00 |
| ADAMTS6 | ENSG00000049192 | 1.11 | 1.78 | 0.41 | 0.73 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.60 | 1.54 | 0.27 | 0.71 | 0.00 | 0.20 | 0.83 | 1.88 | 2.15 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.86 | 6.16 | 0.27 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| NLN | ENSG00000123213 | 3.33 | 0.76 | 0.62 | 1.09 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 1.32 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.90 | 0.81 | 0.69 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CCNB1 | ENSG00000134057 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.56 | 0.38 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SMN2 | ENSG00000205571 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CARTPT | ENSG00000164326 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| AGGF1 | ENSG00000164252 | 0.00 | 2.29 | 0.62 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 0.54 | 0.71 | 0.74 | 0.00 | 0.28 | 0.38 | 1.50 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 1.56 | 1.29 | 0.71 | 0.27 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| CCNH | ENSG00000134480 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 0.38 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CDKL3 | ENSG00000006837 | 1.11 | 0.51 | 0.72 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| HDAC3 | ENSG00000171720 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 1.66 | 1.36 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| NR3C1 | ENSG00000113580 | 0.00 | 1.27 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.00 | 0.71 | 0.00 | 0.39 | 0.28 | 1.69 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 2.44 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 1.25 |
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