Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| HTN3 | ENSG00000205649 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| HTN1 | ENSG00000126550 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CSN3 | ENSG00000171209 | 0.00 | 1.27 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.00 | 1.32 | 0.86 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ENAM | ENSG00000132464 | 1.11 | 3.31 | 0.52 | 0.73 | 0.00 | 1.94 | 2.70 | 0.55 | 1.29 | 1.59 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.56 | 2.82 | 4.72 | 1.23 | 0.98 | 0.57 | 0.56 | 0.20 | 3.13 | 0.86 | 9.48 | 0.27 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| GC | ENSG00000145321 | 0.00 | 1.27 | 0.00 | 0.00 | 0.00 | 0.97 | 2.70 | 0.55 | 0.52 | 1.39 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 1.88 | 2.36 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.66 | 1.08 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| ADAMTS3 | ENSG00000156140 | 0.00 | 3.05 | 0.41 | 1.82 | 0.00 | 1.29 | 0.00 | 2.21 | 0.77 | 3.78 | 0.00 | 1.08 | 0.71 | 0.00 | 0.59 | 0.56 | 3.95 | 3.86 | 0.00 | 0.98 | 0.57 | 0.56 | 0.41 | 1.56 | 0.43 | 2.13 | 2.44 | 0.00 | 0.00 | 0.00 | 3.33 | 1.82 | 0.00 |
| ALB | ENSG00000163631 | 0.00 | 1.53 | 0.00 | 0.00 | 5.71 | 0.65 | 0.00 | 0.55 | 0.77 | 1.59 | 0.00 | 1.08 | 0.00 | 0.00 | 0.20 | 13.06 | 0.56 | 1.50 | 0.00 | 1.72 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 4.27 | 0.00 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| AFP | ENSG00000081051 | 1.11 | 1.27 | 0.10 | 1.09 | 0.00 | 0.65 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.59 | 0.28 | 1.69 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 3.55 | 0.27 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| CXCL8 | ENSG00000169429 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CXCL1 | ENSG00000163739 | 1.11 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CXCL5 | ENSG00000163735 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CDKL2 | ENSG00000138769 | 0.00 | 1.02 | 0.31 | 0.36 | 0.00 | 0.65 | 2.70 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.19 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.78 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| FGF5 | ENSG00000138675 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.56 | 0.19 | 0.86 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 1.56 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| DSPP | ENSG00000152591 | 0.00 | 1.27 | 0.62 | 0.00 | 0.00 | 0.65 | 2.70 | 0.00 | 0.00 | 0.80 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.67 | 1.69 | 0.86 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 2.34 | 0.43 | 4.50 | 1.08 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| DMP1 | ENSG00000152592 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.97 | 2.70 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.28 | 0.94 | 1.29 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 1.36 | 0.00 | 0.20 | 0.00 | 0.89 | 1.82 | 0.00 |
| EIF4E | ENSG00000151247 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.94 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| NFKB1 | ENSG00000109320 | 0.00 | 0.76 | 0.62 | 0.36 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 1.32 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 1.56 | 0.43 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| BDH2 | ENSG00000164039 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PRSS12 | ENSG00000164099 | 0.00 | 1.78 | 0.62 | 0.36 | 2.86 | 1.61 | 0.00 | 1.10 | 0.26 | 0.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.39 | 0.83 | 0.56 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| CCNA2 | ENSG00000145386 | 0.00 | 0.51 | 0.31 | 0.36 | 2.86 | 0.65 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
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