Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PRKAG3 | ENSG00000115592 | 0.00 | 0.00 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| COL4A4 | ENSG00000081052 | 0.00 | 3.56 | 0.93 | 1.46 | 0.00 | 3.87 | 0.00 | 2.76 | 1.80 | 2.19 | 0.00 | 0.54 | 0.36 | 0.00 | 0.20 | 1.67 | 3.01 | 5.79 | 0.00 | 2.94 | 1.15 | 0.00 | 0.41 | 0.00 | 0.86 | 18.72 | 2.98 | 0.00 | 0.20 | 0.00 | 4.21 | 1.82 | 0.00 |
| CCL20 | ENSG00000115009 | 0.00 | 0.25 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| NPPC | ENSG00000163273 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| DUSP28 | ENSG00000188542 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CAPN10 | ENSG00000142330 | 0.00 | 0.25 | 0.31 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 1.13 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| STK25 | ENSG00000115694 | 0.00 | 0.25 | 0.31 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.56 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| RBCK1 | ENSG00000125826 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.71 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| OXT | ENSG00000101405 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| HAO1 | ENSG00000101323 | 0.00 | 1.02 | 0.41 | 1.09 | 0.00 | 1.61 | 2.70 | 0.00 | 0.26 | 1.79 | 0.00 | 0.00 | 0.71 | 0.00 | 0.20 | 0.00 | 1.88 | 2.79 | 0.00 | 0.74 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PLCB4 | ENSG00000101333 | 1.11 | 2.29 | 1.14 | 1.46 | 0.00 | 1.29 | 2.70 | 0.55 | 0.77 | 2.79 | 0.00 | 0.81 | 0.36 | 0.74 | 0.39 | 2.22 | 5.27 | 4.08 | 0.00 | 1.47 | 0.00 | 0.56 | 1.63 | 1.56 | 0.43 | 15.40 | 1.08 | 0.00 | 0.20 | 0.00 | 1.11 | 0.00 | 2.50 |
| OTOR | ENSG00000125879 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| CST4 | ENSG00000101441 | 0.00 | 0.25 | 0.00 | 1.09 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.75 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| CST2 | ENSG00000170369 | 0.00 | 0.25 | 0.31 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| PYGB | ENSG00000100994 | 0.00 | 1.78 | 0.31 | 1.09 | 0.00 | 1.29 | 2.70 | 1.66 | 0.52 | 0.80 | 0.00 | 0.27 | 0.36 | 0.74 | 0.20 | 0.28 | 0.75 | 1.29 | 1.23 | 0.74 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| BPIFB6 | ENSG00000167104 | 1.11 | 2.29 | 0.00 | 0.00 | 0.00 | 1.29 | 0.00 | 0.00 | 0.77 | 0.40 | 0.00 | 0.00 | 0.36 | 0.74 | 0.00 | 0.00 | 1.13 | 2.15 | 0.00 | 0.49 | 0.00 | 0.56 | 0.00 | 0.78 | 0.43 | 1.90 | 1.36 | 0.69 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| BPIFB4 | ENSG00000186191 | 1.11 | 1.27 | 0.41 | 1.46 | 0.00 | 1.94 | 2.70 | 1.10 | 0.26 | 1.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.83 | 1.32 | 2.15 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 1.56 | 1.29 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| AHCY | ENSG00000101444 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.20 | 0.00 | 0.00 | 1.07 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| GHRH | ENSG00000118702 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| WFDC12 | ENSG00000168703 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
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