Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| FABP1 | ENSG00000163586 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| THNSL2 | ENSG00000144115 | 1.11 | 0.76 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 1.69 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| DUSP2 | ENSG00000158050 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.65 | 10.81 | 0.55 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| NMS | ENSG00000204640 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.52 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GLI2 | ENSG00000074047 | 2.22 | 2.80 | 0.62 | 0.73 | 0.00 | 1.29 | 2.70 | 0.55 | 1.03 | 2.39 | 0.00 | 1.08 | 0.00 | 0.00 | 0.20 | 3.33 | 3.58 | 3.00 | 0.00 | 2.21 | 0.57 | 0.00 | 0.61 | 1.56 | 0.43 | 8.06 | 1.36 | 0.00 | 0.20 | 0.83 | 2.88 | 0.00 | 1.25 |
| MAP3K2 | ENSG00000169967 | 0.00 | 1.27 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.54 | 0.00 | 1.47 | 0.00 | 0.83 | 0.75 | 0.21 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.42 | 0.00 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| TUBA3E | ENSG00000152086 | 0.00 | 0.51 | 0.10 | 0.73 | 0.00 | 1.29 | 2.70 | 0.00 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 1.13 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TUBA3D | ENSG00000075886 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.32 | 2.70 | 1.10 | 0.26 | 0.80 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 1.88 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| ZRANB3 | ENSG00000121988 | 2.22 | 2.54 | 0.72 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.52 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.83 | 1.69 | 2.58 | 1.23 | 0.25 | 1.15 | 0.00 | 0.00 | 0.00 | 0.43 | 1.66 | 0.54 | 0.00 | 0.20 | 0.00 | 2.44 | 0.00 | 0.00 |
| HNMT | ENSG00000150540 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 1.93 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| KYNU | ENSG00000115919 | 0.00 | 0.25 | 0.21 | 0.00 | 2.86 | 0.65 | 0.00 | 0.00 | 0.26 | 1.79 | 3.08 | 0.54 | 0.36 | 0.00 | 0.00 | 0.83 | 1.88 | 1.72 | 1.23 | 0.49 | 0.00 | 0.56 | 0.41 | 0.78 | 1.29 | 3.79 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
| STK39 | ENSG00000198648 | 0.00 | 1.02 | 0.00 | 1.46 | 0.00 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PDK1 | ENSG00000152256 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.28 | 1.13 | 0.64 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PDE1A | ENSG00000115252 | 1.11 | 1.53 | 0.31 | 0.73 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 1.88 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 8.53 | 0.54 | 0.00 | 0.20 | 0.00 | 1.33 | 0.00 | 0.00 |
| DUSP19 | ENSG00000162999 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PMS1 | ENSG00000064933 | 0.00 | 1.53 | 1.03 | 1.46 | 0.00 | 1.61 | 0.00 | 0.55 | 0.00 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 1.88 | 2.36 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 1.90 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 0.00 |
| MSTN | ENSG00000138379 | 0.00 | 0.76 | 0.31 | 0.00 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 0.56 | 0.38 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AOX1 | ENSG00000138356 | 0.00 | 1.78 | 0.72 | 0.36 | 0.00 | 0.65 | 0.00 | 1.10 | 1.80 | 1.79 | 1.54 | 1.08 | 0.00 | 0.00 | 0.39 | 1.94 | 3.01 | 3.00 | 0.00 | 1.47 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 5.45 | 1.90 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| PECR | ENSG00000115425 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 1.54 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| IGFBP5 | ENSG00000115461 | 0.00 | 0.00 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.56 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
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