Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| MAP3K10 | ENSG00000130758 | 0.00 | 0.51 | 0.52 | 0.36 | 0.00 | 0.32 | 2.70 | 2.21 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.64 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| SPHK2 | ENSG00000063176 | 1.11 | 2.04 | 0.31 | 0.73 | 0.00 | 0.32 | 2.70 | 1.66 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.56 | 1.13 | 0.21 | 0.00 | 0.98 | 0.00 | 0.00 | 0.20 | 1.56 | 0.86 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| HRC | ENSG00000130528 | 0.00 | 2.04 | 0.62 | 1.46 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.81 | 1.42 | 0.00 | 0.00 | 0.00 | 0.75 | 1.29 | 0.00 | 0.49 | 0.57 | 0.56 | 0.00 | 0.78 | 0.00 | 2.84 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PRMT1 | ENSG00000126457 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.83 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 1.12 | 0.20 | 0.00 | 0.00 | 0.95 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| POLD1 | ENSG00000062822 | 1.11 | 1.53 | 0.52 | 0.73 | 0.00 | 0.65 | 0.00 | 1.10 | 0.77 | 1.79 | 0.00 | 0.81 | 1.42 | 0.00 | 0.39 | 0.83 | 0.75 | 1.50 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.42 | 1.08 | 0.00 | 0.20 | 0.00 | 3.77 | 0.00 | 0.00 |
| KLK1 | ENSG00000167748 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.83 | 1.51 | 0.43 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| LAIR2 | ENSG00000167618 | 0.00 | 0.25 | 0.31 | 0.36 | 2.86 | 0.65 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 0.00 | 0.94 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| GALP | ENSG00000197487 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| MATN3 | ENSG00000132031 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.19 | 0.43 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 1.42 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| FKBP1B | ENSG00000119782 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TP53I3 | ENSG00000115129 | 0.00 | 0.76 | 0.41 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.81 | 0.00 | 0.74 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| RBKS | ENSG00000171174 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CAPN14 | ENSG00000214711 | 1.11 | 0.00 | 0.41 | 0.36 | 2.86 | 0.97 | 0.00 | 1.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| XDH | ENSG00000158125 | 2.22 | 1.78 | 0.83 | 2.55 | 0.00 | 0.65 | 0.00 | 2.76 | 1.55 | 1.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.59 | 1.39 | 2.07 | 4.51 | 0.00 | 0.98 | 0.00 | 1.12 | 0.00 | 0.78 | 0.00 | 12.09 | 3.25 | 0.69 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| VIT | ENSG00000205221 | 0.00 | 3.31 | 0.62 | 0.00 | 0.00 | 0.32 | 5.41 | 0.00 | 1.03 | 0.80 | 0.00 | 0.00 | 0.00 | 0.00 | 0.98 | 0.83 | 1.88 | 1.50 | 0.00 | 0.25 | 0.00 | 1.12 | 0.20 | 0.78 | 0.00 | 3.08 | 0.81 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| EIF2AK2 | ENSG00000055332 | 0.00 | 1.78 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.00 | 0.00 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 1.18 | 0.54 | 0.00 | 0.20 | 0.00 | 0.89 | 0.00 | 1.25 |
| CDKL4 | ENSG00000205111 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.94 | 0.86 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| MAP4K3 | ENSG00000011566 | 0.00 | 2.04 | 0.10 | 2.19 | 0.00 | 0.32 | 2.70 | 1.10 | 0.77 | 0.80 | 0.00 | 0.81 | 0.00 | 1.47 | 0.20 | 0.28 | 2.07 | 1.72 | 0.00 | 1.47 | 0.57 | 0.00 | 0.00 | 2.34 | 0.00 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PKDCC | ENSG00000162878 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 1.36 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| REG3G | ENSG00000143954 | 0.00 | 0.25 | 0.10 | 0.00 | 2.86 | 0.65 | 0.00 | 1.66 | 0.00 | 1.39 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.00 | 4.14 | 4.08 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.43 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 1.82 | 0.00 |
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