Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| SERPINB10 | ENSG00000242550 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.39 | 0.28 | 1.13 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 2.37 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| CNDP1 | ENSG00000150656 | 0.00 | 0.51 | 0.62 | 0.73 | 0.00 | 0.65 | 0.00 | 0.00 | 1.29 | 1.39 | 1.54 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 0.94 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 2.37 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| ZADH2 | ENSG00000180011 | 0.00 | 0.76 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.74 | 0.39 | 0.00 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DOT1L | ENSG00000104885 | 0.00 | 3.56 | 0.72 | 1.09 | 0.00 | 2.26 | 0.00 | 0.55 | 0.77 | 1.39 | 0.00 | 0.54 | 1.78 | 0.00 | 0.20 | 1.11 | 2.26 | 1.72 | 0.00 | 0.00 | 0.00 | 0.00 | 0.81 | 0.00 | 0.43 | 2.61 | 0.81 | 0.00 | 0.20 | 0.83 | 1.33 | 0.00 | 0.00 |
| DPP9 | ENSG00000142002 | 0.00 | 0.51 | 0.31 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 1.11 | 0.75 | 1.07 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.78 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 2.66 | 0.00 | 0.00 |
| LONP1 | ENSG00000196365 | 1.11 | 1.78 | 0.10 | 0.36 | 0.00 | 0.65 | 0.00 | 1.66 | 0.26 | 1.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 1.51 | 0.86 | 0.00 | 0.25 | 0.57 | 0.56 | 0.20 | 0.00 | 0.43 | 0.71 | 0.54 | 0.69 | 0.20 | 0.00 | 1.11 | 0.00 | 0.00 |
| NRTN | ENSG00000171119 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.00 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CLPP | ENSG00000125656 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RETN | ENSG00000104918 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 |
| PIN1 | ENSG00000127445 | 1.11 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DNMT1 | ENSG00000130816 | 0.00 | 2.04 | 0.93 | 1.82 | 0.00 | 0.97 | 0.00 | 0.00 | 0.77 | 1.59 | 0.00 | 1.08 | 0.36 | 0.74 | 0.00 | 0.83 | 0.94 | 1.07 | 0.00 | 1.23 | 0.00 | 0.00 | 0.41 | 0.78 | 0.43 | 2.61 | 1.08 | 0.69 | 0.20 | 0.00 | 2.44 | 0.00 | 0.00 |
| ACP5 | ENSG00000102575 | 0.00 | 1.27 | 0.41 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.54 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| RLN3 | ENSG00000171136 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 1.54 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.00 | 0.21 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.83 | 0.00 | 0.00 | 0.00 |
| BRD4 | ENSG00000141867 | 0.00 | 2.04 | 0.41 | 1.46 | 0.00 | 1.61 | 2.70 | 2.21 | 1.29 | 1.39 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 1.67 | 0.75 | 2.15 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 2.34 | 0.43 | 3.55 | 1.08 | 0.00 | 0.00 | 0.83 | 2.22 | 0.00 | 0.00 |
| PDE4C | ENSG00000105650 | 0.00 | 1.78 | 0.83 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 1.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 1.93 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 0.54 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| CCNE1 | ENSG00000105173 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PEPD | ENSG00000124299 | 0.00 | 0.51 | 0.10 | 0.36 | 2.86 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.83 | 0.38 | 0.86 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| KRTDAP | ENSG00000188508 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| DMKN | ENSG00000161249 | 0.00 | 0.51 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.52 | 0.60 | 0.00 | 1.08 | 0.36 | 0.00 | 0.20 | 1.11 | 1.51 | 1.29 | 0.00 | 0.25 | 0.00 | 0.56 | 0.00 | 0.78 | 0.86 | 1.66 | 0.27 | 0.00 | 0.00 | 0.83 | 1.11 | 0.00 | 0.00 |
| DYRK1B | ENSG00000105204 | 0.00 | 1.02 | 0.41 | 0.00 | 0.00 | 0.32 | 2.70 | 0.55 | 0.26 | 1.39 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.56 | 0.75 | 1.50 | 1.23 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
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