Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| DUSP14 | ENSG00000276023 | |||||||||||||||||||||||||||||||||
| KLHL10 | ENSG00000161594 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.28 | 1.69 | 1.07 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| TUBG1 | ENSG00000131462 | 0.00 | 1.53 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.54 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.00 | 0.00 | 0.20 | 0.00 | 0.44 | 0.00 | 0.00 |
| TUBG2 | ENSG00000037042 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 1.29 | 0.00 | 0.55 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.56 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 0.24 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| C1QL1 | ENSG00000131094 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| MAP3K14 | ENSG00000006062 | |||||||||||||||||||||||||||||||||
| TAC4 | ENSG00000176358 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CHAD | ENSG00000136457 | 0.00 | 0.76 | 0.10 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.54 | 1.07 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| SCPEP1 | ENSG00000121064 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.56 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
| MTMR4 | ENSG00000108389 | 0.00 | 2.29 | 0.62 | 1.46 | 0.00 | 0.97 | 0.00 | 2.21 | 0.77 | 1.00 | 0.00 | 0.81 | 0.36 | 0.74 | 0.00 | 1.67 | 1.13 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 2.13 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| GALK1 | ENSG00000108479 | 0.00 | 0.51 | 0.00 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PRPSAP1 | ENSG00000161542 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 1.08 | 0.36 | 0.74 | 0.00 | 0.00 | 0.56 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TK1 | ENSG00000167900 | 0.00 | 0.51 | 0.31 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.89 | 1.82 | 0.00 |
| BIRC5 | ENSG00000089685 | 0.00 | 0.51 | 0.00 | 1.46 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.25 |
| ENGASE | ENSG00000167280 | 0.00 | 0.76 | 0.31 | 1.09 | 2.86 | 0.32 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.00 | 0.71 | 0.00 | 0.59 | 1.67 | 0.75 | 0.86 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 0.78 | 0.00 | 1.42 | 0.81 | 0.00 | 0.20 | 0.00 | 1.55 | 0.00 | 0.00 |
| IMPA2 | ENSG00000141401 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PSMA8 | ENSG00000154611 | 0.00 | 1.27 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.19 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PIK3C3 | ENSG00000078142 | 1.11 | 2.80 | 0.41 | 1.09 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 1.47 | 0.00 | 0.00 | 2.26 | 2.58 | 1.23 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 2.17 | 0.00 | 0.00 | 0.83 | 1.33 | 1.82 | 0.00 |
| GRP | ENSG00000134443 | 0.00 | 0.51 | 0.00 | 0.36 | 0.00 | 0.65 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| SERPINB5 | ENSG00000206075 | 0.00 | 0.76 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.77 | 0.00 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 1.32 | 1.07 | 0.00 | 0.49 | 0.57 | 0.00 | 0.61 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
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