Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| HTR1D | ENSG00000179546 | 0.00 | 1.53 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 2.21 | 0.52 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.69 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| CELSR1 | ENSG00000075275 | 0.00 | 3.05 | 0.93 | 4.01 | 0.00 | 2.58 | 5.41 | 2.21 | 1.03 | 3.39 | 1.54 | 2.17 | 1.42 | 0.74 | 1.18 | 2.50 | 2.26 | 3.65 | 0.00 | 0.74 | 0.57 | 0.00 | 0.61 | 1.56 | 2.16 | 6.16 | 1.90 | 1.39 | 0.61 | 0.83 | 6.43 | 1.82 | 1.25 |
| ADGRD1 | ENSG00000111452 | 1.11 | 2.29 | 0.62 | 1.46 | 0.00 | 1.29 | 0.00 | 1.10 | 0.77 | 1.20 | 1.54 | 0.54 | 1.07 | 0.00 | 0.59 | 0.28 | 3.01 | 1.72 | 0.00 | 0.25 | 1.72 | 0.00 | 0.41 | 0.78 | 0.43 | 3.08 | 1.36 | 0.00 | 0.20 | 0.00 | 1.77 | 0.00 | 0.00 |
| TMED9 | ENSG00000184840 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| WNT4 | ENSG00000162552 | 1.11 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.19 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.27 | 0.00 | 0.20 | 0.00 | 0.44 | 1.82 | 0.00 |
| DMD | ENSG00000198947 | 2.22 | 8.91 | 4.34 | 10.95 | 2.86 | 9.35 | 2.70 | 6.63 | 2.84 | 9.16 | 1.54 | 1.63 | 1.78 | 2.21 | 1.57 | 5.56 | 12.99 | 12.02 | 1.23 | 2.94 | 1.72 | 0.00 | 0.81 | 7.81 | 3.45 | 6.87 | 8.94 | 2.08 | 0.41 | 1.65 | 10.42 | 3.64 | 0.00 |
| SLC8A3 | ENSG00000100678 | 0.00 | 1.27 | 0.31 | 0.73 | 2.86 | 0.65 | 0.00 | 0.00 | 0.52 | 2.79 | 0.00 | 0.81 | 1.07 | 0.00 | 0.39 | 0.56 | 4.33 | 3.65 | 0.00 | 1.96 | 1.15 | 0.00 | 0.41 | 0.78 | 1.72 | 10.43 | 1.36 | 0.00 | 0.41 | 0.00 | 1.77 | 1.82 | 0.00 |
| PTPRN2 | ENSG00000155093 | 1.11 | 1.27 | 0.72 | 1.09 | 0.00 | 1.94 | 0.00 | 1.10 | 1.03 | 0.40 | 3.08 | 1.08 | 0.36 | 0.00 | 0.00 | 1.94 | 4.14 | 3.22 | 0.00 | 1.72 | 1.15 | 0.00 | 0.00 | 0.78 | 0.00 | 8.77 | 1.63 | 0.00 | 0.00 | 0.00 | 2.88 | 0.00 | 0.00 |
| ABCA4 | ENSG00000198691 | 0.00 | 2.04 | 0.72 | 2.92 | 0.00 | 2.58 | 2.70 | 0.00 | 1.29 | 2.19 | 0.00 | 0.54 | 1.42 | 2.21 | 0.59 | 3.06 | 2.26 | 4.29 | 0.00 | 1.72 | 1.15 | 0.00 | 0.61 | 0.78 | 1.29 | 8.29 | 1.36 | 0.00 | 0.00 | 0.00 | 3.99 | 1.82 | 0.00 |
| ABCG2 | ENSG00000118777 | 0.00 | 2.04 | 0.10 | 0.73 | 2.86 | 0.65 | 0.00 | 0.00 | 1.55 | 0.80 | 0.00 | 0.00 | 1.07 | 0.00 | 0.20 | 0.56 | 1.69 | 2.15 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| TSHR | ENSG00000165409 | 0.00 | 1.27 | 0.62 | 0.36 | 0.00 | 1.29 | 0.00 | 1.10 | 0.26 | 0.60 | 0.00 | 0.27 | 0.00 | 0.00 | 0.39 | 0.00 | 2.45 | 1.72 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.43 | 2.61 | 0.54 | 0.00 | 0.20 | 0.83 | 0.67 | 0.00 | 0.00 |
| F3 | ENSG00000117525 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| FLRT2 | ENSG00000185070 | 0.00 | 3.31 | 0.52 | 1.09 | 0.00 | 1.61 | 0.00 | 2.21 | 0.26 | 1.39 | 0.00 | 0.54 | 0.71 | 0.74 | 0.20 | 1.11 | 2.07 | 4.08 | 1.23 | 0.74 | 1.72 | 0.56 | 0.61 | 4.69 | 0.43 | 4.98 | 4.88 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SLC22A5 | ENSG00000197375 | 0.00 | 0.00 | 0.21 | 0.36 | 2.86 | 0.00 | 0.00 | 1.10 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.56 | 0.38 | 0.86 | 0.00 | 0.25 | 0.57 | 0.56 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 1.25 |
| SLC22A4 | ENSG00000197208 | 0.00 | 1.53 | 0.10 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.60 | 0.00 | 0.81 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.55 | 0.00 | 0.00 |
| CLU | ENSG00000120885 | 0.00 | 0.25 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.00 | 0.75 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 1.66 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| KCNC4 | ENSG00000116396 | 1.11 | 2.54 | 0.00 | 0.73 | 0.00 | 0.65 | 0.00 | 0.55 | 0.77 | 0.40 | 0.00 | 0.54 | 0.71 | 0.00 | 0.00 | 0.28 | 0.75 | 1.07 | 0.00 | 0.25 | 0.57 | 0.00 | 0.41 | 2.34 | 0.86 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| SCARB1 | ENSG00000073060 | 1.11 | 0.25 | 0.41 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.86 | 0.00 | 0.49 | 0.00 | 0.56 | 0.41 | 0.00 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 1.25 |
| NT5E | ENSG00000135318 | 0.00 | 1.27 | 0.52 | 0.73 | 0.00 | 0.00 | 2.70 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.38 | 1.29 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SLC16A3 | ENSG00000141526 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.57 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.83 | 0.67 | 0.00 | 0.00 |
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