Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| PATE4 | ENSG00000237353 | 0.00 | 0.00 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| FKBP4 | ENSG00000004478 | 2.22 | 0.51 | 0.10 | 1.09 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 1.54 | 0.00 | 1.07 | 0.00 | 0.20 | 0.28 | 0.38 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.61 | 0.00 | 0.43 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CCND2 | ENSG00000118971 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.00 | 2.70 | 0.00 | 0.52 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.83 | 0.38 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| DYRK4 | ENSG00000010219 | 0.00 | 1.53 | 0.21 | 0.00 | 2.86 | 1.61 | 0.00 | 1.66 | 0.52 | 1.59 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 1.51 | 1.93 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 1.29 | 2.84 | 0.00 | 0.00 | 0.41 | 0.83 | 1.33 | 0.00 | 0.00 |
| ACRBP | ENSG00000111644 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.19 | 1.50 | 1.23 | 0.74 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PTPN6 | ENSG00000111679 | 1.11 | 0.51 | 0.00 | 0.00 | 0.00 | 0.32 | 8.11 | 0.00 | 0.77 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.56 | 0.75 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 0.00 |
| RBP5 | ENSG00000139194 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.28 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| DUSP16 | ENSG00000111266 | 0.00 | 1.02 | 0.62 | 0.00 | 0.00 | 0.97 | 2.70 | 0.00 | 0.26 | 1.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 1.29 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.78 | 0.00 | 1.18 | 0.00 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 0.00 |
| PIK3C2G | ENSG00000139144 | 1.11 | 2.04 | 0.83 | 0.73 | 0.00 | 2.58 | 2.70 | 1.10 | 2.06 | 1.99 | 0.00 | 0.27 | 1.07 | 0.00 | 0.20 | 1.39 | 2.26 | 3.65 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.78 | 2.59 | 11.85 | 1.08 | 1.39 | 0.20 | 0.00 | 2.22 | 0.00 | 0.00 |
| LDHB | ENSG00000111716 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.43 | 0.71 | 0.54 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PTHLH | ENSG00000087494 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.97 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.75 | 0.21 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| YARS2 | ENSG00000139131 | 0.00 | 1.27 | 0.10 | 1.09 | 0.00 | 0.97 | 0.00 | 1.10 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.28 | 1.51 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 0.24 | 0.27 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| YAF2 | ENSG00000015153 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.60 | 0.00 | 0.00 | 0.00 | 0.74 | 0.00 | 0.28 | 0.00 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TUBA1B | ENSG00000123416 | 0.00 | 0.76 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.80 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.00 | 0.19 | 0.21 | 0.00 | 0.49 | 0.57 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TUBA1A | ENSG00000167552 | 0.00 | 1.27 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.74 | 0.20 | 0.28 | 0.56 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 1.08 | 0.69 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| NR4A1 | ENSG00000123358 | 1.11 | 0.51 | 0.21 | 0.00 | 0.00 | 0.97 | 0.00 | 0.55 | 0.26 | 0.20 | 1.54 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 1.93 | 1.23 | 1.23 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 1.82 | 0.00 |
| KRT8 | ENSG00000170421 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.65 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.66 | 0.81 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| CSAD | ENSG00000139631 | 1.11 | 0.51 | 0.21 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.80 | 0.00 | 0.27 | 0.36 | 0.74 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.98 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| RARG | ENSG00000172819 | 0.00 | 2.80 | 0.41 | 1.46 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 2.59 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.83 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| PDE1B | ENSG00000123360 | 0.00 | 0.76 | 0.31 | 1.09 | 0.00 | 1.29 | 2.70 | 1.10 | 0.00 | 0.80 | 0.00 | 1.08 | 0.36 | 0.00 | 0.20 | 0.56 | 1.32 | 1.29 | 0.00 | 0.49 | 0.57 | 0.56 | 0.20 | 0.78 | 0.43 | 2.84 | 0.81 | 0.00 | 0.00 | 0.00 | 1.11 | 1.82 | 0.00 |
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