Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| GGPS1 | ENSG00000152904 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.32 | 2.70 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.19 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.08 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| AKR1E2 | ENSG00000165568 | 0.00 | 1.78 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.38 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| UCN3 | ENSG00000178473 | 0.00 | 0.25 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TUBAL3 | ENSG00000178462 | 1.11 | 0.00 | 0.10 | 0.36 | 0.00 | 1.29 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.56 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 4.27 | 0.27 | 0.00 | 0.00 | 0.00 | 1.33 | 1.82 | 0.00 |
| UCMA | ENSG00000165623 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| PTPN20 | ENSG00000204179 | 0.00 | 0.51 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RBP3 | ENSG00000265203 | |||||||||||||||||||||||||||||||||
| CHAT | ENSG00000070748 | 0.00 | 0.25 | 0.21 | 1.46 | 0.00 | 0.97 | 0.00 | 2.21 | 1.55 | 1.39 | 0.00 | 0.00 | 0.00 | 0.00 | 0.39 | 1.11 | 2.45 | 4.29 | 0.00 | 0.25 | 1.15 | 0.00 | 0.61 | 0.78 | 0.43 | 4.50 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| DUPD1 | ENSG00000188716 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 0.75 | 0.86 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| GLUD1 | ENSG00000148672 | 0.00 | 0.76 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.40 | 0.00 | 0.00 | 0.36 | 0.00 | 0.59 | 0.56 | 0.56 | 1.07 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| RBP4 | ENSG00000138207 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.19 | 0.21 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| DUSP5 | ENSG00000138166 | 0.00 | 0.25 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 1.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.59 | 0.28 | 0.56 | 1.72 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.24 | 0.54 | 0.00 | 0.20 | 0.00 | 0.67 | 0.00 | 0.00 |
| OAT | ENSG00000065154 | 0.00 | 0.25 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.27 | 0.71 | 0.74 | 0.00 | 0.56 | 0.19 | 0.64 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SCGB1C1 | ENSG00000188076 | 0.00 | 0.51 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SIRT3 | ENSG00000142082 | 0.00 | 0.51 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 1.54 | 0.00 | 0.00 | 0.00 | 0.39 | 0.28 | 0.38 | 0.43 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.86 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| INS-IGF2 | ENSG00000129965 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.28 | 0.94 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| HBB | ENSG00000244734 | 0.00 | 0.00 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.00 | 0.56 | 1.29 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| PSMA1 | ENSG00000129084 | 0.00 | 0.51 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 1.00 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| SAA1 | ENSG00000173432 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.00 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| PRMT3 | ENSG00000185238 | 0.00 | 0.25 | 0.31 | 0.00 | 5.71 | 1.29 | 0.00 | 0.00 | 0.26 | 1.20 | 0.00 | 0.27 | 0.00 | 0.74 | 0.00 | 0.28 | 1.13 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.41 | 0.78 | 0.00 | 0.24 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
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