Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| DUSP23 | ENSG00000158716 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| DUSP12 | ENSG00000081721 | 1.11 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.95 | 0.27 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| SCYL3 | ENSG00000000457 | 0.00 | 1.53 | 0.41 | 0.73 | 0.00 | 0.00 | 2.70 | 0.55 | 0.52 | 0.00 | 0.00 | 0.54 | 0.00 | 0.00 | 0.78 | 0.28 | 0.38 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 0.00 | 0.43 | 1.18 | 1.36 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| MYOC | ENSG00000034971 | 0.00 | 1.02 | 0.21 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 0.83 | 1.88 | 1.50 | 0.00 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 2.61 | 0.81 | 0.00 | 0.00 | 0.00 | 1.33 | 0.00 | 0.00 |
| KLHL20 | ENSG00000076321 | 0.00 | 0.51 | 0.41 | 0.73 | 2.86 | 0.32 | 0.00 | 0.55 | 0.52 | 0.20 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 1.13 | 1.50 | 0.00 | 0.25 | 0.00 | 0.00 | 0.20 | 1.56 | 0.00 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| UCHL5 | ENSG00000116750 | 0.00 | 0.76 | 0.10 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.94 | 1.07 | 1.23 | 0.25 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CFHR4 | ENSG00000134365 | 0.00 | 2.29 | 0.41 | 0.36 | 0.00 | 1.29 | 0.00 | 2.21 | 1.29 | 2.59 | 0.00 | 1.08 | 0.71 | 0.00 | 0.20 | 0.56 | 2.64 | 4.94 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 2.34 | 0.43 | 7.82 | 2.17 | 0.69 | 0.00 | 0.00 | 1.77 | 0.00 | 0.00 |
| NEK7 | ENSG00000151414 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.20 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.19 | 0.43 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| NR5A2 | ENSG00000116833 | 1.11 | 1.78 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 2.21 | 0.52 | 0.80 | 0.00 | 0.27 | 0.00 | 0.00 | 0.20 | 0.56 | 2.26 | 1.93 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.55 | 0.81 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| CHI3L1 | ENSG00000133048 | 0.00 | 0.76 | 0.62 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.00 | 0.56 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 0.89 | 1.82 | 0.00 |
| KISS1 | ENSG00000170498 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.56 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| CDK18 | ENSG00000117266 | 0.00 | 0.00 | 0.31 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.83 | 0.75 | 0.86 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.66 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| DYRK3 | ENSG00000143479 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.56 | 0.64 | 0.00 | 0.00 | 0.57 | 0.00 | 0.00 | 1.56 | 0.00 | 1.90 | 0.81 | 0.00 | 0.00 | 0.00 | 2.22 | 0.00 | 0.00 |
| IL20 | ENSG00000162891 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 0.00 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| NENF | ENSG00000117691 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| RPS6KC1 | ENSG00000136643 | 0.00 | 2.80 | 0.21 | 0.00 | 0.00 | 0.65 | 0.00 | 0.00 | 0.26 | 1.79 | 0.00 | 0.81 | 0.71 | 0.00 | 0.00 | 0.28 | 1.13 | 2.15 | 0.00 | 1.47 | 0.00 | 0.56 | 0.20 | 2.34 | 0.00 | 2.61 | 1.08 | 0.00 | 0.00 | 0.00 | 1.55 | 1.82 | 1.25 |
| PTPN14 | ENSG00000152104 | 0.00 | 2.04 | 0.72 | 0.73 | 0.00 | 0.97 | 2.70 | 1.66 | 1.03 | 2.99 | 0.00 | 0.54 | 1.42 | 0.74 | 0.59 | 2.50 | 1.88 | 2.58 | 1.23 | 0.49 | 0.57 | 1.12 | 0.20 | 1.56 | 0.00 | 1.18 | 0.81 | 0.00 | 0.00 | 0.83 | 3.55 | 0.00 | 0.00 |
| ESRRG | ENSG00000196482 | 0.00 | 1.53 | 0.31 | 0.36 | 0.00 | 1.29 | 5.41 | 0.55 | 0.52 | 1.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.20 | 1.39 | 2.64 | 4.94 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 1.56 | 0.00 | 3.32 | 3.25 | 0.00 | 0.00 | 0.00 | 2.00 | 0.00 | 1.25 |
| EPRS | ENSG00000136628 | 1.11 | 2.04 | 0.62 | 1.46 | 2.86 | 1.61 | 0.00 | 1.10 | 0.26 | 1.00 | 0.00 | 0.00 | 0.36 | 1.47 | 0.20 | 0.56 | 3.20 | 3.00 | 0.00 | 0.74 | 0.00 | 0.00 | 0.20 | 1.56 | 0.43 | 2.13 | 2.71 | 0.69 | 0.61 | 0.00 | 3.55 | 0.00 | 0.00 |
| DUSP10 | ENSG00000143507 | 0.00 | 0.51 | 0.41 | 0.36 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 0.20 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 1.69 | 1.07 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.78 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
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