Mutation
The putative cancer-causing PDGs driven by somatic mutations were predicted by integration of five complementary methods to identify the genes with mutations that have significant signs of positive selection during tumor evolution.
Summary of mutation frequency of the PDGs in each cancer type
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| HGNC Symbol | Ensembl Gene ID | ACC_Mut% | BLCA_Mut% | BRCA_Mut% | CESC_Mut% | CHOL_Mut% | COAD_Mut% | DLBC_Mut% | ESCA_Mut% | GBM_Mut% | HNSC_Mut% | KICH_Mut% | KIRC_Mut% | KIRP_Mut% | LAML_Mut% | LGG_Mut% | LIHC_Mut% | LUAD_Mut% | LUSC_Mut% | MESO_Mut% | OV_Mut% | PAAD_Mut% | PCPG_Mut% | PRAD_Mut% | READ_Mut% | SARC_Mut% | SKCM_Mut% | STAD_Mut% | TGCT_Mut% | THCA_Mut% | THYM_Mut% | UCEC_Mut% | UCS_Mut% | UVM_Mut% |
| TXNDC5 | ENSG00000239264 | 1.11 | 0.76 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.26 | 0.40 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| EDN1 | ENSG00000078401 | 0.00 | 0.25 | 0.21 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.56 | 0.19 | 0.21 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.90 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 1.25 |
| COL11A2 | ENSG00000204248 | 0.00 | 2.29 | 0.31 | 2.55 | 0.00 | 1.61 | 0.00 | 2.76 | 1.55 | 1.39 | 0.00 | 0.54 | 0.71 | 0.00 | 0.20 | 2.22 | 2.45 | 4.29 | 0.00 | 1.72 | 0.00 | 0.56 | 0.41 | 0.78 | 1.29 | 8.77 | 0.54 | 0.00 | 0.41 | 0.00 | 3.33 | 1.82 | 0.00 |
| MAPK14 | ENSG00000112062 | 0.00 | 0.51 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.40 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 0.38 | 0.43 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| PGC | ENSG00000096088 | 0.00 | 0.25 | 0.10 | 0.36 | 0.00 | 0.00 | 0.00 | 1.10 | 0.00 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.56 | 0.64 | 0.00 | 0.49 | 0.57 | 0.00 | 0.20 | 0.78 | 0.43 | 1.18 | 1.08 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CCND3 | ENSG00000112576 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.00 | 2.70 | 0.55 | 0.00 | 0.00 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.00 | 0.19 | 0.21 | 1.23 | 0.00 | 0.00 | 0.00 | 0.20 | 0.00 | 0.00 | 0.24 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| TTBK1 | ENSG00000146216 | 2.22 | 1.27 | 0.52 | 0.36 | 0.00 | 3.23 | 0.00 | 1.66 | 1.80 | 1.39 | 0.00 | 0.54 | 0.71 | 0.74 | 0.20 | 1.67 | 3.39 | 1.72 | 0.00 | 0.74 | 0.00 | 0.00 | 0.61 | 0.00 | 0.00 | 5.21 | 0.81 | 0.69 | 0.00 | 0.00 | 0.89 | 0.00 | 0.00 |
| IMPG1 | ENSG00000112706 | 1.11 | 2.29 | 0.83 | 0.73 | 0.00 | 1.29 | 5.41 | 2.21 | 2.06 | 2.39 | 0.00 | 0.27 | 0.36 | 0.00 | 0.39 | 1.11 | 2.64 | 4.94 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 3.13 | 0.43 | 6.64 | 1.63 | 0.00 | 0.20 | 0.83 | 1.11 | 3.64 | 0.00 |
| TTK | ENSG00000112742 | 0.00 | 1.78 | 0.41 | 1.46 | 0.00 | 0.97 | 2.70 | 2.21 | 0.52 | 0.60 | 0.00 | 0.54 | 0.36 | 0.74 | 0.39 | 0.00 | 3.01 | 3.22 | 1.23 | 0.74 | 0.57 | 0.00 | 0.00 | 0.78 | 0.43 | 0.95 | 1.63 | 0.69 | 0.41 | 0.00 | 3.55 | 0.00 | 0.00 |
| RTN4IP1 | ENSG00000130347 | 0.00 | 1.02 | 0.10 | 0.00 | 0.00 | 0.32 | 0.00 | 0.00 | 0.26 | 0.80 | 0.00 | 0.54 | 0.00 | 0.00 | 0.00 | 0.00 | 1.32 | 0.64 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.18 | 0.54 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| TUBE1 | ENSG00000074935 | 0.00 | 0.51 | 0.31 | 0.36 | 0.00 | 0.32 | 0.00 | 0.55 | 0.00 | 0.60 | 0.00 | 0.00 | 0.36 | 0.00 | 0.00 | 0.28 | 0.00 | 0.86 | 0.00 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 1.08 | 0.00 | 0.00 | 0.00 | 0.67 | 0.00 | 0.00 |
| ALDH8A1 | ENSG00000118514 | 1.11 | 0.76 | 0.52 | 0.00 | 0.00 | 0.65 | 2.70 | 1.66 | 0.00 | 0.60 | 0.00 | 0.54 | 0.36 | 0.00 | 0.00 | 0.28 | 2.26 | 1.50 | 0.00 | 0.74 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 1.42 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| MAP3K5 | ENSG00000197442 | 0.00 | 2.54 | 0.93 | 1.09 | 0.00 | 1.29 | 0.00 | 1.66 | 0.52 | 0.80 | 0.00 | 0.81 | 0.00 | 0.00 | 0.59 | 0.28 | 1.69 | 1.93 | 0.00 | 1.23 | 1.15 | 0.00 | 0.00 | 0.78 | 1.29 | 5.21 | 0.27 | 0.00 | 0.00 | 0.00 | 2.22 | 1.82 | 1.25 |
| MAP3K4 | ENSG00000085511 | 1.11 | 4.07 | 1.14 | 1.82 | 0.00 | 3.87 | 0.00 | 0.00 | 0.77 | 1.79 | 0.00 | 1.90 | 1.07 | 0.74 | 0.59 | 1.67 | 3.39 | 1.29 | 1.23 | 0.74 | 0.00 | 0.56 | 0.20 | 1.56 | 0.00 | 3.79 | 1.08 | 0.00 | 0.00 | 0.83 | 3.10 | 5.45 | 0.00 |
| UPP1 | ENSG00000183696 | 0.00 | 0.00 | 0.21 | 0.00 | 0.00 | 0.00 | 0.00 | 0.55 | 0.26 | 0.40 | 1.54 | 0.00 | 0.36 | 0.00 | 0.00 | 0.56 | 0.94 | 0.64 | 0.00 | 0.25 | 0.00 | 0.00 | 0.41 | 0.00 | 0.00 | 0.71 | 0.00 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
| CCL26 | ENSG00000006606 | 0.00 | 0.25 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.43 | 0.00 | 0.25 | 0.57 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| TAC1 | ENSG00000006128 | 0.00 | 0.25 | 0.00 | 0.73 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.27 | 0.00 | 0.00 | 0.00 | 0.00 | 0.38 | 1.07 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.47 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| SRPK2 | ENSG00000135250 | 1.11 | 0.51 | 0.21 | 1.09 | 0.00 | 0.32 | 0.00 | 1.10 | 0.52 | 1.79 | 0.00 | 0.27 | 0.36 | 0.00 | 0.20 | 0.28 | 1.13 | 1.29 | 1.23 | 0.49 | 0.00 | 0.00 | 0.00 | 0.00 | 0.86 | 0.71 | 0.27 | 0.00 | 0.00 | 0.00 | 0.22 | 0.00 | 0.00 |
| IMPDH1 | ENSG00000106348 | 0.00 | 0.25 | 0.21 | 0.73 | 0.00 | 0.32 | 0.00 | 0.00 | 0.52 | 0.40 | 0.00 | 0.27 | 0.71 | 0.00 | 0.00 | 0.28 | 0.94 | 1.50 | 0.00 | 0.98 | 0.57 | 0.00 | 0.00 | 0.00 | 0.43 | 1.18 | 0.27 | 0.00 | 0.00 | 0.00 | 1.11 | 0.00 | 0.00 |
| PTN | ENSG00000105894 | 0.00 | 1.02 | 0.21 | 0.00 | 0.00 | 0.97 | 2.70 | 0.55 | 0.26 | 0.40 | 0.00 | 0.00 | 0.00 | 0.00 | 0.20 | 0.28 | 1.13 | 0.64 | 1.23 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.71 | 0.81 | 0.00 | 0.00 | 0.00 | 0.44 | 0.00 | 0.00 |
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